Core Dartmouth Activities Andrew J. Saykin, Psy.D., ABPP-CN John D. West, M.S. Robert M. Roth, Ph.D. Brain Imaging Laboratory Dartmouth Medical School / DHMC NA-MIC National Alliance for Medical Image Computing

Overview National Alliance for Medical Image Computing  Volumetric ROI studies  Diffusion tensor imaging  ROI analyses  Tractography  Functional magnetic resonance imaging  Planned applications  Related work  Current Collaborations

National Alliance for Medical Image Computing ROI Volumetric Studies Manual Tracing and 3D Modeling of ROIs using Slicer ROIs: Hippocampus Amygdala Entorhinal cortex Caudate nucleus Putamen Nucleus accumbens Thalamus Fornix Mammillary bodies

National Alliance for Medical Image Computing ROI Volumetric Studies Illustration of 2D Traces and 3D Models of ROIs

National Alliance for Medical Image Computing Diffusion Tensor Imaging FA in Uncinate Fasciculus ROI in Schizophrenia using Slicer Based on Kubicki et al., 2002

National Alliance for Medical Image Computing Diffusion Tensor Imaging Healthy Control Patient with Schizophrenia C1 - rostrum and genu C2 - anterior truncus C3 - middle truncus C4 - posterior truncus C5 - isthmus and splenium [Wang et al. 2005] Integration of Corpus Callosum Subregion ROIs with Tractography

National Alliance for Medical Image Computing Functional MRI Cognitive Task Development and Validation: Probing Frontal-Temporal Circuitry Primary Tasks: Working memory Episodic memory Semantic memory Secondary Tasks (other Circuitry) Self-reflection Reward Planning

National Alliance for Medical Image Computing Functional MRI Prospective Data Collection on 1.5T Magnet: Interim Analysis of Patients with Schizophrenia and Controls Controls Patientsp (n=8) (n=13) Age (yrs.) 30.8 (7.1) 36.4 (10.3) NS Educ (yrs.)* 16.9 (2.4) 14.6 (1.9).05 Sex (M,F) 3, 5 9, 3 NS WRAT Reading111.5 (4.7) (10.5) NS CVLT-II Total (6.4) 38.6 (10.4).001 * matched for parental SES

National Alliance for Medical Image Computing Functional MRI n-Back Working Memory Task

National Alliance for Medical Image Computing Functional MRI – Behavioral Performance Interim analysis

National Alliance for Medical Image Computing Functional MRI FMRI Activation During 3-Back in Schizophrenia Controls N = 8 Patients N = 12 Simple Effects p =.01 Interim analysis

National Alliance for Medical Image Computing Functional MRI FMRI Activation During 3-Back in Schizophrenia Controls > Patients p =.01 Patients > Controls Interim analysis

National Alliance for Medical Image Computing Functional MRI Verbal Encoding/Retrieval Episodic Memory Task

National Alliance for Medical Image Computing Functional MRI – Behavioral Performance Verbal Encoding/Retrieval Episodic Memory Task Interim analysis

National Alliance for Medical Image Computing Functional MRI – Behavioral Performance Verbal Encoding/Retrieval Episodic Memory Task Interim analysis

National Alliance for Medical Image Computing Functional MRI FMRI Activation During Continuous Auditory-Verbal Memory (new > old word contrast) in Patients with Schizophrenia Patients N = 7 p =.01 Interim analysis Verbal Encoding/Retrieval Episodic Memory Task

National Alliance for Medical Image Computing Collaborations and Progress  Shape Analysis with UNC Group: Martin Styner, Guido Gerig  Hippocampal Shape - Dartmouth Data: SPHARM Overall Mean Left Mean Right Mean Skeleton-based subdivision

National Alliance for Medical Image Computing Collaborations and Progress  fMRI in Slicer – fMRIEngine - Wendy Plesniak and Haiying Liu  Met Dec. 14 th, 2005 to discuss progress and future improvements to be made  Have supplied motor data from two controls to test results from module and compare with results from SPM2  fMRI tasks – Brigham group  Porting of our tasks to BWH  Meeting with Marek Kubicki on Dec. 20 th, 2005 to demonstrate our tasks and how we utilize them  Training session at BWH  Tara McHugh visited to get in depth training in Slicer for tracing structures – Dec. 1 st, 2005

National Alliance for Medical Image Computing Collaborations and Progress  Working with Steve Pieper to test 64-bit Linux version of Slicer  Worked with Steve Pieper, Gordon Kindlmann, Xiaodong Tao, and Josh Snyder to convert Dartmouth DTI data to nrrd format and solve lingering orientation issues  DTI Path of Interest – MGH – David Tuch and Josh Snyder  Dartmouth request for tools to help relate DTI fiber tract pathways to connections in fMRI identified circuits  Collaboration to implement DTI Path of Interest Program at Dartmouth site  Successful initial results on NAMIC01 healthy control by both Josh Snyder at MGH and John West at Dartmouth  Plans: integrate functional ROIs derived from fMRI tasks

National Alliance for Medical Image Computing DTI Path of Interest – Initial Results  Collaboration with David Tuch & Josh Snyder (MGH)  Description – program finds the optimal path between two or more ROIs using probability statistics  Implementation  C-code, Matlab and FSL scripts to generate optimal path  Slicer for visualization and tracing of input ROIs  Full implementation in Slicer as module is a future project  Initial results from NAMIC01 healthy control

National Alliance for Medical Image Computing DTI Path of Interest – Initial Results Hippocampal ROI to Ventral Prefrontal ROI Uncinate Fasciculus

National Alliance for Medical Image Computing DTI Path of Interest – Initial Results Receptive Speech Area ROI to Expressive Speech Area ROI Arcuate Fasciculus

National Alliance for Medical Image Computing DTI Path of Interest – Initial Results Hippo ROI to Expressive Speech Area ROI Using Receptive Speech Area ROI as Guide Arcuate Fasciculus

National Alliance for Medical Image Computing Planned Applications & Developments Integration of fMRI and DTI data, including tractography (see tool “wish list”) Effective and functional connectivity during cognitive tasks (see tool “wish list”) Examine structural (ROI, DTI) and functional (fMRI) correlates of symptoms and cognition Expand use of methods to other populations  bipolar disorder, OCD, MCI/AD, MS, TBI, epilepsy, other disorders

National Alliance for Medical Image Computing Neuroimaging Research Center 3T Magnet

National Alliance for Medical Image Computing Neuroimaging Research Center 3T Magnet

National Alliance for Medical Image Computing Brain Imaging Laboratory: People FACULTY PIs (Psychiatry): Laura A. Flashman, Ph.D. Alan I. Green, M.D. Thomas W. McAllister, M.D. Brenna C. McDonald, Psy.D. Robert M. Roth, Ph.D. Andrew J. Saykin, Psy.D. Heather A. Wishart, Ph.D. POST-DOCTORAL FELLOWS: Howard Cleavinger, Ph.D. (Epilepsy) Ellen Crouse, Ph.D. (MCI, chemotherapy) Nancy Koven, Ph.D. (Schizophrenia) Nadia Paré Ph.D. (MCI, ADNI) Jo Cara Pendergrass, Ph.D. (Schizophrenia) KEY TECHNICAL COLLABORATORS: Konstantinos Arfanakis, Ph.D. (DTI; IIT) Fillia Makedon, Ph.D. (Computer Science) James C. Ford, Ph.D. (Computer Science) Li Shen, Ph.D. (CS, UMASS-Dartmouth) Jason Moore, Ph.D. (Comp Genetics) BIL COORDINATOR Heather Pixley, B.A. IMAGE ANALYSTS & SYSTEMS ADMIN: John MacDonald, M.A. Tara McHugh, M.A. Paul Wang, B.A. John West, M.S. STUDY COORDINATORS: Mary Hynes, RN (TBI) Ariel Rosen, B.A. (MS) NEUROSCIENCE TECHNICIANS: Carrie Kruck, B.A. (chemotherapy) Margaret Nordstrom, B.A. (MCI) RESEARCH MRI TECHNOLOGISTS: Jorge A. Forero Alice E. Davison

National Alliance for Medical Image Computing Dartmouth Brain Imaging Laboratory December, 2005