No more broken hearts Presented by: Jeffrey Avila Janae Gonzales Burt Matthews Quantitative Trait Loci Analysis for Plasma HDL-Cholesterol Concentrations.

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Presentation transcript:

No more broken hearts Presented by: Jeffrey Avila Janae Gonzales Burt Matthews Quantitative Trait Loci Analysis for Plasma HDL-Cholesterol Concentrations and Atherosclerosis Susceptibility Between Inbred Mouse Strains C57BL/6J and 129S1/SvImJ Arterioscler. Thromb. Vasc. Biol. 2004;24; Naoki Ishimori et.al.

QTL What is it?

QTL What is it? What does it tell us?

QTL What is it? What does it tell us? Why is it important?

Overview of study B6X129

Overview of study B6X F2 Progeny Females

Overview of study B6X F2 Progeny Females High Fat Diet

Overview of study B6X F2 Progeny Females High Fat Diet Identify regions on chromosomes using QTL analysis

Phenotypic Measurements Plasma HDLAortic Lesions Micenmg/dlum B610 41±2 951± x10 106±40 F18 84±30 F ±1 228±44

QTL Analysis

Relevance 6 loci HDL + 5 Loci atherosclerosis suseptability identified The Future Lipoproteins Medications

Ways to increase my HDL levels Exercise Increase intake of Omega 3 fatty acids Eat Onions

A special thanks to…. Randy Von Smith Tobias Beckwith Dr. Brook Milligan NMSU RISE Program