Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971. OVEREATING STUDIES (individual subjects)

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Presentation transcript:

Salans, L.B., et al. Journal of Clinical Investigation 50: , OVEREATING STUDIES (individual subjects)

Salans, L.B., et al. Journal of Clinical Investigation 50: , OVEREATING STUDIES (individual subjects)

OVEREATING STUDIES (individual subjects) Salans, L.B., et al. Journal of Clinical Investigation 50: , 1971.

OVEREATING STUDIES (individual subjects) Salans, L.B., et al. Journal of Clinical Investigation 50: , 1971.

OVEREATING STUDIES (individual subjects) Salans, L.B., et al. Journal of Clinical Investigation 50: , 1971.

OVEREATING STUDIES (individual subjects) Salans, L.B., et al. Journal of Clinical Investigation 50: , 1971.

TNF α IL-6 Angiotensin Vasoconstriction ↓ NO Adiponectin ↓ Fibrinolysis PAI-1 Insulin Resistance Insulin Resistance Resistin Inflammation Insulin Resistance

NUTRITION IN OBESITY Caloric Intake Percent Fat

OBESITY Oscai et al J Lipid Research 13: , Sedentary Free Eaters Sedentary Pair Weighted Exercise Calories per Day

OBESITY Percent Fat (%) Body Weight (g)

OBESITY Fat Cell Size Fat Cell Number

Wilmore JH, Research Quarterly for Exercise and Sport 54: , Changes in Lean & Fat Mass with Training - Men

Wilmore JH, Research Quarterly for Exercise and Sport 54: , Changes in Lean & Fat Mass with Training - Women

Total weight, fat mass & lean mass changes with diet and exercise Miller, WC et al International Journal of Obesity 21: , 1997

Lea n Fat Zuti & Golding, Physician & SportsMedicine 4:49-55, 1978 Weight Change (lbs) Lean vs. Fat Mass Loss with Diet & Exercise

Lea n Fat Franklin, B., et al. Research Quarterly Weight Change (lbs) Lean vs. Fat Mass Loss In Overweight Adults

Jakicic, et al. JAMA 282: , 1999 SHORT vs. LONG BOUTS OF EXERICSE

Jakicic, et al. JAMA 282: , 1999 ADHERENCE Minutes per week

Jakicic, et al. JAMA 282: , 1999 Weight Loss

Lifestyle Activity vs. Exercise is Weight Loss Dunn, A.L. et al JAMA 281: , 1999

MORBID OBESITY Reduce body fat in obese: Hill JO et al Physical Activity, Fitness, and Health: International Proceedings and Consensus statement, p , No Wt Loss Trend Wt Loss

Fogelholm, et al. Arch Int Medicine 160: , 2000 PHYSICAL ACTIVITY & WEIGHT MAINTENANCE

Walden et al, Am J Clin Nutr 47: , N= 20 upper N= 20 lower N= 20 upper N= 20 lower LOWER: Lost Abd & Glut LOWER: Lost Abd & Glut UPPER: Lost more on WHR Lost only from Abd Lost more weight UPPER: Lost more on WHR Lost only from Abd Lost more weight

Salans, L.B., et al. Journal of Clinical Investigation 50: , OVEREATING STUDIES (individual subjects)

Tremblay, A., Int J Obesity 8: , EXERCISE & THE FAT CELL

Lee, C.D., et al. American Journal of Clinical Nutrition 69: , 1999 Fitness & Fatness

EXERCISE & NUTRITION Percent Body Fat (%) Pitts, et al Am J Physiol 246:R495, 1984

EXERCISE & METABOLIC RATE Poehlman, E.T., Med Sci Sports Exerc 21: , 1989

EXERCISE & FOOD INTAKE Neiman, D.C., J A, Dietetic Assoc 90: , 1990

Postprandial Lipemia and Exercise Aldred, H.E, et al Metabolism 43: , 1994

Baseline 1 year * * * * * * *

Baseline 1 year * interaction

Baseline 1 year