Management of premalignant lesions of gastric cancer A survey of European Gastroenterologists Class 16 Porto, 2008/2009 Professor Doutor Altamiro da Costa Pereira Authors: Ana Silva, Andreia Carvalho, Carlos Laranja, Cláudia Leite, Daniel Oliveira, Francisco Silva, Henrique Sousa, Joana Matos, João Cardoso, Luís Vale, Mariana Santiago, Pedro Morais, Renato Ramos, Rui Loureiro, Tatiana Salazar; Supervisors: Prof. Doutor Mário Ribeiro e Dr. Ricardo Santos

INTRODUCTION RESEARCH QUESTION PARTICIPANTS AND METHODS PARTICIPANTS AND METHODS Management of premalignant lesions of gastric cancer RESULTS REFERENCES AIMS

Premalignant lesions Gastric Cancer High mortality and morbidity Lack of practice recommendations Worldwide incidence INTRODUCTION Management of premalignant lesions of gastric cancer

Premalignant lesions Atrophic chronic gastritis (ACG) Intestinal metaplasia (IM) Dysplasia (Dys) Management of premalignant lesions of gastric cancer INTRODUCTION

Which are the main options concerning diagnosis, monitoring and treatment of premalignant lesions of gastric cancer that are being taken by European Gastroenterologists? Management of premalignant lesions of gastric cancer RESEARCH QUESTION

Management of premalignant lesions of gastric cancer To assess the practice in terms of diagnosis, monitoring and treatment of premalignant lesions of gastric cancer To compile these management options into a database AIMS

Management of premalignant lesions of gastric cancer PARTICIPANTS AND METHODS PARTICIPANTS AND METHODS Type of study - observational and cross-sectional Participants’ selection Data collection Variables description Statistical analysis of data

Sampling Management of premalignant lesions of gastric cancer Target Population: Gastroenterologists performing research in this field Articles search Authors’ contacts database Authors’ contacts database Participants’ selection PARTICIPANTS AND METHODS PARTICIPANTS AND METHODS

Management of premalignant lesions of gastric cancer Sent by Opened ended questions Closed ended questions PARTICIPANTS AND METHODS PARTICIPANTS AND METHODS Data collection Query

Dependent variables: –Management options takenManagement options taken Independent variables: –Type of lesionsType of lesions –Author/DepartmentAuthor/Department –Place of workPlace of work –…–… Management of premalignant lesions of gastric cancer PARTICIPANTS AND METHODS PARTICIPANTS AND METHODS Variables description Categorical variables

Management of premalignant lesions of gastric cancer Descriptive statistics - absolute and relative frequencies - 95% confidence intervals Inferencial statistics - Chi- square/contigency tables(or Fisher’s)Inferencial statistics - Chi- square/contigency tables(or Fisher’s) - statistical significance – 0.05 PARTICIPANTS AND METHODS PARTICIPANTS AND METHODS Using SPSS Statistical analysis

RESULTS Nr. of s sent  132 Nr. of s delivered: 132 Nr. of s not delivered: 0 Answered: 16 No response yet: 116 Management of premalignant lesions of gastric cancer Fluxogram1: s response

RESULTS Management of premalignant lesions of gastric cancer Image1: SPSS database image

Management of premalignant lesions of gastric cancer RESULTS 0 - Does your answers reflect your own practice or your department(s)? TotalN% Query14 Valid cases14100 Missing00 DescriptionN%Cum.%Cum. Department7507 My own Table 1: Question results

RESULTS Management of premalignant lesions of gastric cancer Pratical attitudes Diagnosis Follow-up Erradication H. Pylori Atrophic chronic gastritis (ACG) [a;b] Intestinal metaplasia (IM) Dysplasia (Dys) Low grade High grade Table 2: Summary results

Low response rate -Until now we have 12.12% of response Send query second time Management of premalignant lesions of gastric cancer RESULTS Problems and limitations

Management of premalignant lesions of gastric cancer 1. Contacts’ database 2. Querys’ answers 3. Management options’ database 4. Online publication RESULTS

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