Brian C. Springer, MHA Executive Director Siteman Cancer Center Barnes-Jewish Hospital & Washington U. School of Med CCSG-CTSA Interactions Michael Bertram, PhD, MBA Associate Director for Administration UAB Comprehensive Cancer Center Kara Newton Administrative Director UAB Center for Clinical & Translational Science

Overview Overview of CTSAs Development of the Applications Collaborative Culture Relationship at the Site Visit Future Directions We encourage discussion along the way …

Overview of CTSAs Strategic Goals Across the Consortium 1.National Clinical and Translational Research Capability 2.The Training and Career Development of Clinical and Translational Scientists 3.Consortium-Wide Collaborations 4.The Health of our Communities and the Nation 5.T1 Translational Research

Overview of CTSAs

Each CTSA institution has created a home for clinical and translational science. Input from the NIH and other federal agencies, industry, and private and community organizations helps guide the work of every CTSA institution.

Our Respective CTSAs Funded in Collaborating Institutions 5 Clinical Research Cores 12 Other Research Cores 2 Research Education Programs 4 Community Engagement Programs Funded in 2008 Unique Drug Discovery Component Novel Collaborations with Southern Research Institute & HudsonAlpha Institute for Biotechnology 9 Research Cores 2 Research Education Programs Dual Community Engagement Program One Great Community & Deep South Network THE UNIVERSITY OF ALABAMA AT BIRMINGHAM Center for Clinical and Translational Science

… Briefly, Application Development … Council for Center Directors Council for Translational Research (CCC Represented) CCTS Biomedical Informatics Synergized Institutional efforts: CCC, UAB Health System, UAB IT Catalyzed the establishment of a Division of Biomedical Informatics Council of Centers Council of Administrators Broad collaboration in all areas between ICTS and SCC Leveraging of programs and relationships … … and infrastructure and grant materials

Collaborative Culture Shared Leadership Advisory Boards & Executive Committees, Core Directors, Deep South Networks, Council for Translational Research & Working Groups Broad Institutional Initiatives Informatics, caBIG, Clinical Data Warehouse, Drug Discovery Program, Clinical Research Operations, SOM Strategic Planning, VA Research Activities Leveraging Stakeholders’ Investments

Collaborative Culture Strong Institutional Investment Shared Leaders (ICTS/SCC) New Seminar Series Monthly Management Meetings (ICTS/SCC) –Best Practices (membership, citations, EAB) –Joint Project –Ability to Represent Joint Interests

ICTS 28 shared resources SCC 14 shared resources Shared Resources 5 shared cores + 1 developmental Biostatistics, Biomedical Informatics, Human Imaging (IRAT/HIU), Proteomics, Tissue, Plus Developmental (HAMLET)

Shared Resources Subsidy for Siteman members Subsidy for ICTS members Personnel (ctr grant) Personnel (JIT grants) Personnel (other)SuppliesEquip Dep Other $$$ Philosophy behind multiple subsidies: For two years, shared electronic user survey for all ICTS and SCC shared resources.

Transformative Partnerships Academic Drug Discovery and Development at UAB & SRI: Molecular Library High through-put screening 3D structure of targets Medicinal chemistry with in silico screening Preclinical toxicology and ADME analysis Alabama Drug Discovery Alliance UAB School of Medicine UAB CCTS Southern Research Institute UAB CCC

Pilot Projects FY11 over $1 million in co-sponsored projects FY11 over $120,000 in CTSA partnerships and $150,000 in Drug Discovery Alliance projects from UAB CCC CCTS/University-wide Centers match program CCC/CCTS Drug Discovery Projects Nascent Projects Panel (shared mentorship) Streamlined online application & review process

Pilot Projects Robust BJHF-ICTS Funding Program (> $1 million/year) Many SCC Pilot Programs (2011 > $1 million) Sharing credit for each others’ successes

Information Resources Publications – joint input Web resources Shared resource listings

Information Resources University-Wide Center Listserv For Announcements & Opportunities CCC Monthly e-Newsletter, Quarterly Magazine, Facebook CCTS Weekly e-Digest, Quarterly Newsletter, Twitter

Institutional Impact Key Components of SOM Strategic Planning –Cancer 1 of 6 priority research themes –CCTS 1 of 5 cross-disciplinary platforms Catalyze Research Center Interactions Representation for Campus-wide Systems –Integrated Information Systems –Shared Facility Coordination –Phase I Clinical Trials Unit Priority –Enterprise Wide Adoption caBIG CTMS Together, We Are Stronger

Institutional Impact SCC as a trailblazer Strength of both centers in partnership to foster institutional change Increased grant funding More collaborative culture

Best Practices? So what have you tried that has worked???

Site Visits CCTS Director participated in CCC Site Visit highlighting collaborations during the Director’s overview

Future Directions Greater consolidation Greater leverages CTSA transition to new NIH Institute targeted for October 2011 National Center for Advancing Translational Sciences (NCATS) –Emphasis on T1 research –New and more effective therapeutics –New NIH-FDA partnership activities

Last Thoughts