Immunology Stack Slackers Facts by Mike Ori
Disclaimer The information represents my understanding only so errors and omissions are probably rampant. It has not been vetted or reviewed by faculty. The source is our class notes. The document can mostly be used forward and backward. I tried to mark questionable stuff with (?). If you want it to look pretty, steal some crayons and go to town. Finally… If you’re a gunner, buck up and do your own work.
SLE antibodies
Anti-phospholipid Anti-smith Anti-dsDNA
SLE mortality factors
Short term: active disease (renal) and infection Long term: chronic renal failure, heart failure, malignancies, infection
SLE treatment
Immune suppression with cyclophosphamide and corticosteroids
Rheumatoid arthritis antibodies
RF
What is Rheumatoid Factor?
IgM antibodies directed against an immunoglobin such as IgG
RA description
Autoimmune attack on synovium leads to synovial overgrowth (fronding) onto articular cartilage causing irreversible joint destruction and malformation.
Other RA affected areas
Nodules in soft tissue, inflammation of the eye, vasculitis.
RA Immune cell involvement
CD4+ T and B cell infiltrates into joins with lymphoid follicle formation
Sjogren syndrome antibodies
Anti-SS-A/Ro Anti-SS-B/La
Sjogren description
Autoimmune destruction of exocrine gland epithelium particularly that of the salivary and lacrimal glands. Formation of germinal centers is possible.
Sjogren cells
CD4+ cells. NOTE: Although ab are present, they do not appear to be the principle cause of the damage. (Robbins)
Sjogren’s linked disease
40x increased risk of B cell lymphoma
Scleroderma Ab
Anti-scl 70 Anti-nucleolar
Systemic sclerosis (Sceroderma) description
Progressive fibrosis located throughout the body particularly the skin and to a lesser extent the GI tract, kidneys, heart, muscles, and lungs.
Scleroderma cells
CD4+ T cells activate fibroblasts through unknown mechanisms.
Systemic Vasculitis Antibodies
Anti-neutrophil cytoplasmic antigen (ANCA)
Systemic vasculitis description
Immune response that results in either the deposition of Ab/Ag complexes or the binding of Ab in situ to elements of the endothelium. This results in a range of diseases involving the vasculature including wegener granulomatosis and churg-strauss. The reaction may range from mild to fatal.
Systemic vasculitis causes
Drugs and viruses