By: Destiny Sanchez Efren Miranda Mirna Rocha.  A Quantitative Trait is a trait of a gene that can be described with numbers.  QTL (Quantitative Trait.

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Presentation transcript:

By: Destiny Sanchez Efren Miranda Mirna Rocha

 A Quantitative Trait is a trait of a gene that can be described with numbers.  QTL (Quantitative Trait Loci) are the locations on chromosomes where the genes that influence quantitative traits reside. (Robert J. Brooker) QTL Phenotype

 HDL Cholesterol (High Density Lipoproteins)  LDL Cholesterol (Low Density Lipoproteins)  Atherosclerosis

 Heart attacks and Stroke are a result of atherosclerosis  A build up of fat around arterial walls will eventually lead to complete arterial blockage  Could result in death

 To perform QTL analysis on inbred mice in order to determine the effects of a high fat diet on HDL concentrations and Atherosclerosis susceptibility.

C57BL/6J (B6) X 129S1/SvImJ(129) B6x129 (F1) F2 Progeny

 Fed high diet to 294 (F2) female mice for 14 weeks  Measured plasma HDL concentrations  Measured size of aortic fatty-streak lesions  Performed QTL analysis

MicenPlasma HDLAortic Lesions B61041±2951± ±40 F1884±30 F229481±1228±44

 B6 mice displayed low HDL and High Atherosclerosis susceptibility  F2 intercross - 6 Loci for HDL were identified and 5 loci for heart disease susceptibility  129 mice had high HDL levels and Atherosclerosis resistance

 A high fat diet plays a large role in the damaging of the aortic system leading to heart disease.  The QTL for traits are located on the same regions of the chromosomes in mice and humans.

High fiber diet Vegetables Low Fat Lean Protein

 Brooker, Robert J.. Genetics Analysis and Principles. New York, NY: McGraw-Hill,  8

Dr. Randy Von Smith Tobias Beckwith Dr. Brook Milligan RISE Program

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