Biomolecular and Cellular Engineering Microbes Enzymes Biomolecules Metabolic Engineering Biopolymer Antibody Nano-Devices, Sensors, Environmental, Biosynthetic and Biomedical Applications Synthetic Biology Protein Engineering Directed Evolution
Research Interest Biomolecular Tools
Artificial Cellulosomes 1.Found in anaerobic microbes 2.Hydrolyze cellulose up to 50-fold faster due to synergy 3. Interaction between dockerin to cohesin is species specific Bayer et al., 2006
Synthetic Yeast Consortia
Virus detection and drug discovery Influenza
In situ Monitoring of Virus Replication Using Molecular Beacons Nucleus Uncoating Translation RNA replication Fixation with para-formaldehyde and permeabilization Triton X-100
In vivo detection of Coxsackie B6 virus in BGMK cells PlasDIC (t = 0 min) PlasDIC (t = 18 hr) Cells infected with 10 3 PFU, M.O.I.≈ 0.5 (15 min to 18 hr) Yeh et al. PNAS, , 2008
Acknowledgement 9 Graduate Students and 1 Postdoc