Architectural and Biochemical Adaptations in Skeletal Muscle and Bone Following Rotator Cuff Injury in a Rat Model by Eugene J. Sato, Megan L. Killian,

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Presentation transcript:

Architectural and Biochemical Adaptations in Skeletal Muscle and Bone Following Rotator Cuff Injury in a Rat Model by Eugene J. Sato, Megan L. Killian, Anthony J. Choi, Evie Lin, Alexander D. Choo, Ana E. Rodriguez-Soto, Chanteak T. Lim, Stavros Thomopoulos, Leesa M. Galatz, and Samuel R. Ward J Bone Joint Surg Am Volume 97(7): April 1, 2015 ©2015 by The Journal of Bone and Joint Surgery, Inc.

Architectural measurements of the supraspinatus and infraspinatus muscles indicate that the mass and physiological cross-sectional area were progressively reduced in the tenotomy+BTX group. Eugene J. Sato et al. J Bone Joint Surg Am 2015;97: ©2015 by The Journal of Bone and Joint Surgery, Inc.

Representative micro-CT images depicting axial (Fig. 2-A), sagittal (Fig. 2-B), and coronal (Fig. 2- C) views of the scapula. Eugene J. Sato et al. J Bone Joint Surg Am 2015;97: ©2015 by The Journal of Bone and Joint Surgery, Inc.

Humeral head measurements for bone volume fraction (bone volume [BV]/total volume [TV]) (Fig. 3-A), trabecular spacing (TbSp) (Fig. 3-B), trabecular thickness (TbTh) (Fig. 3-C), and trabecular number (TbN) (Fig. 3-D). Eugene J. Sato et al. J Bone Joint Surg Am 2015;97: ©2015 by The Journal of Bone and Joint Surgery, Inc.

Titin molecular weight (MW) was decreased in the supraspinatus (Fig. 4-A) and infraspinatus (Fig. 4-B) muscles following tenotomy, compared with the control values, but with different time courses. Eugene J. Sato et al. J Bone Joint Surg Am 2015;97: ©2015 by The Journal of Bone and Joint Surgery, Inc.