… Rejection Transplantation Biology:. Kidney rejection:

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Presentation transcript:

… Rejection Transplantation Biology:

Kidney rejection:

Allograft rejection: specificity and memmory.

Adoptive transfer of skin allograft rejection.

MHC-matching: microcytotoxicity assay

Microcytotoxicity test.

Mixed Lymphocyte Reaction.

Luminex Cross-matching Assay: Checks for the presence of pre-existing anti-HLA antibodies in recipient serum to assess the risk of hyperacute rejection.

Organ Rejection: 1.Hyperacute (immediate) : hours Pre-existing antibodies. 2.Acute: (weeks) Cell-mediated – MHC-mismatch. 3.Chronic (months, years) minor histocompatibility antigens.

Transplantation of blood: blood transfusion.

Hyperacute rejection of kidney graft.

Allo-antibodies and chronic rejection.

Black: Azathioprine + corticosteroids Blue: Cyclosporin A + corticosteroids

Fraternal twins cattle

“Transfusion of a goat’s blood” (1892) Jules Andler ( ).