Functional Diffusion Maps (fDMs) for Brain Tumor Treatment Response Monitoring Benjamin M. Ellingson, Ph.D. Assistant Professor of Radiology Dept. of Radiological.

Slides:

Advertisements

Similar presentations

Radiologic Imaging Defines the local extent of a tumor Can be used to stage malignant disease Aids in the diagnosis Monitoring tumor changes after treatment.

Advertisements

Guidelines for a standardized MRI protocol for MS:

A Proposal for BMS (Dasatinib) in GIST Jon Trent, MD, PhD Assistant Professor Dept. of Sarcoma Medical Oncology The University of Texas, M. D. Anderson.

A. HRICHI, S. KOUKI, M. LANDOULSI,R. AOUINI, I. GANZOUI, S.BOUGUERRA, Y. AROUS, H. BOUJEMAA, N. BEN ABDALLAH Radiology service, Main Military hospital.

B.M. Ellingson 1,2, M.G. Malkin 1,3,4, S.D. Rand 1,2, J.M. Connelly 3, C. Quinsey 4 P.S. LaViolette 1,5, D.P. Bedekar 1,2, and K.M. Schmainda 1,2,5 B.M.

Pancreas Cancer Nimisha K. Parekh, MD, MPH

Diffusion Physics H 2 O in the body is always in random motion due to thermal agitation B.M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen.

Methods to Differentiate Radiation Induced Necrosis and Recurrent Disease in Gliomas Lars Ewell University of Arizona Medical Center Department of Radiation.

Stereotactic Radiosurgery Jimmy Johannes Physics 335 – Spring 2004 Final Presentation

Public Health Julie C. Chapman, PsyD Director of Neuroscience War Related Illness & Injury Study Center Veterans Affairs Medical Center, Washington, DC.

Diffusion MRI is sensitive to brain tumor cell density Clinical ADC and cell density are negatively correlated (Sugahara, 1999; Lyng, 2000; Chenevert,

Pre-Tx 18 F-FDOPA PET Pre-Tx T1+C Post-Tx 18 F-FDOPA PET Difference Post-Pre Tx 18 F-FDOPA PET IOIS: 3401 Benjamin M. Ellingson, Ph.D., Dept. of Radiological.

DegenerationRegeneration Traumatic Injury Degenerative Disease Radiation/Chemotherapy Brain Tumors Stem Cells & Regenerative Medicine B.M. Ellingson, Ph.D.,

Brain Tumors Maria Rountree. Most common types of brain tumors The most common childhood tumors are: The most common childhood tumors are: 1. Astrocytoma.

BRAIN TUMOR. What is it?  Brain neoplasms are a diverse group of primary (nonmetastatic) tumors arising from one of the many different cell types within.

Case Study 24 Craig Horbinski, M.D., Ph.D.. You receive a consult case from an outside hospital on a brain biopsy from a 51 y/o male with a left sided.

Taylor J Greenwood, MD, Adam Wallace, MD, Aseem Sharma, MD, Jack Jennings, MD, PhD.

Comparison of MRI Perfusion and PET-CT in Differentiating Brain Tumor Progression from Radiation Injury after Cranial Irradiation T. Jonathan Yang, M.D.

Update on 18 F-Fluorodeoxyglucose/Positron Emission Tomography and Positron Emission Tomography/ Computed Tomography Imaging of Squamous Head and Neck.

THE CORRELATIONS OF 3D PSEUDO-CONTINUOUS ARTERIAL SPIN LABELING AND DYNAMIC SUSCEPTIBILITY CONTRAST PERFUSION MRI IN BRAIN TUMORS Delgerdalai Khashbat,

Case Study 50 Edward D. Plowey. Case History The patient is a 2 year old girl with normal birth and developmental histories who presented with new onset.

Imaging Questions in Ovarian Cancer Susanna I. Lee, MD, PhD.

Imaging examinations of breasts

Author Name 2, Author Name 5 1 Dept. of Neurology, 2 Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA To demonstrate.

Disclosures Paid Consultant, MedQIA LLC Paid Consultant, Agios Pharmaceuticals, Inc. Consultant, Genentech Consultant, Siemens Medical Systems B.M. Ellingson,

ASNR 2012 Methodology for Imaging Genomics of Gliomas

The Mind’s Eye: Imaging Structure and Function in the Living Brain Daniel K. Sodickson, MD, PhD Vice-Chair for Research, Department of Radiology Director,

Chiba Cancer Center, Chiba, Japan Shintaro Iwata Tsukasa Yonemoto Yoko Hagiwara Takeshi Ishii Division of Orthopedic Surgery Akinobu Araki Dai Ikebe Division.

Diffusion Physics H 2 O in the body is always in random motion due to thermal agitation B.M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen.

Disclosures Paid Consultant, MedQIA LLC Paid Consultant, Agios Pharmaceuticals, Inc. Consultant, Genentech Consultant, Siemens Medical Systems B.M. Ellingson,

1 Computational Modeling in Quantitative Cancer Imaging Biomedical Science and Engineering Conference 18 March 2009 Tom Yankeelov, Nkiruka Atuegwu, John.

Oregon Health & Science University and Northwest PADRECC

Dennis Bourdette, MD VA MS Center of Excellence-West and

WERKGROEP HERSENTUMOREN vzw Study Group Brain Tumours RECENT ADVANCES IN THE BRAIN IMAGING A PATIENTS OPINION European Parliament, Brussels.

Neuroimaging in Neuropsychiatry

Neuroradiology.

Structural and Functional Neuroimaging in the Diagnosis of Dementia John M. Ringman, M.D. Assistant Professor UCLA Department of Neurology.

Anaplastic thyroid cancer based on ATA guideline for Management of Patients with ATC. Thyroid. 2012;22: R3 이정록.

Surgery for Metastatic Brain Tumor from Breast Cancer

A Circulating Tumor Cell (CTC) Assay for Tracking Treatment Response in Glioma Melody Ju, Gary D Kao, David Steinmetz, Dana Patsch, Michelle Alonso-Basanta,

Guidelines for the Use of Imaging In the Management of Myeloma Department of Haematology, University College Hospital, London, UK British Journal of Haematology,

In The Name of God. Multiple Sclerosis and Normal MRI new modalities for problems solving.

Intratumoral topography of CNS gliomas revealed by diffusion tensor imaging: correlations with tumor volume and grade A. Jakab 1, P. Molnár 2, M. Emri.

Axonal loss in the pathology of MS: consequences for understanding the progressive phase of the disease C Bjartmar, J.R Wujek, B.D Trapp Journal of.

C. P. Loizou1, C. Papacharalambous1, G. Samaras1, E. Kyriakou2, T

CORRELATION OF PHYSICAL EVALUATION AND MRI OF CERVICAL LYMPH NODE WITH HISTOPATHOLOGICAL FINDINGS IN ORAL SQUAMOUS CELL CARCINOMA: AN AMBIDIRECTIONAL STUDY.

PURPOSE & INTRODUCTION

Fig. 7. A 70-year-old woman with invasive lobular cancer involving right breast underwent breast MRI. (a, b) On axial breast MRI, segmental clumped nonmass.

Applying the New Multiple Sclerosis Guidelines to Clinical Practice

Brain imaging prior to lung cancer resection

Nat. Rev. Neurol. doi: /nrneurol

Neuroretinitis in patients with multiple sclerosis

Intracranial Infections in Neurosurgical Practice

MR Perfusion and Diffusion Values in Gliomas

Figure 1. A: T1-weighted MRI shows enhanced lesion with peripheral edema on left frontal area, compatible with high grade glioma. B: Left frontal area.

Carcinoma of the Liver By: Renee Alta.

Predict “invasive component” within ductal carcinoma in situ – the breast MRI features and clinicopathologic factors ? Hung-Wen Lai, MD, PhD1,4, Dar-Ren.

Figure 1 Perivenous distribution of multiple sclerosis lesions

PBL-2 NEUROSCIENCE Dr. Abdulrahman AL-Shudifat Neurosurgery Dept.

Figure Brain MRI of the patient throughout the disease course(A) Brain MRI at the time of cerebral toxoplasmosis diagnosis (a) and after 1 month of toxoplasmosis.

Nat. Rev. Neurol. doi: /nrneurol

Figure 1 Cerebral MRI during the disease course Cerebral MRI with multiple cerebral supratentorial lesions during the disease course: periventricular lesions.

BASICS OF DIFFUSION MRI

Case Study 35 Henry Armah, M.D., M.Phil..

Types of biomarkers/biosignatures to be used for cardiovascular disease. Types of biomarkers/biosignatures to be used for cardiovascular disease. There.

Figure MRI brain comparison prior and after treatment and brain biopsy findings MRI brain comparison prior and after treatment and brain biopsy findings.

Bar graph of ADC values (s/mm2) for tumor, contralateral normal tissue, ipsilateral normal tissue, and edema for the group of 15 patients with high-grade.

Fig. 9. A 56-year-old woman, who underwent chemotherapy due to advanced gastric cancer, complained of swelling and erythema of left breast. She underwent.

ADC(x 10-3 mm2 /s)±standard diviation

Figure. (A) Photograph of the patient’s scalp shows the large necrotic skin tumor. Figure. (A) Photograph of the patient’s scalp shows the large necrotic.

Presentation transcript:

Functional Diffusion Maps (fDMs) for Brain Tumor Treatment Response Monitoring Benjamin M. Ellingson, Ph.D. Assistant Professor of Radiology Dept. of Radiological Sciences David Geffen School of Medicine at UCLA B.M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011

Diffusion MRI is sensitive to tumor cell density Clinical ADC and cell density are negatively correlated (Sugahara, 1999; Lyng, 2000; Chenevert, 2000; Gaurain, 2001; Nonomura, 2001; Guo, 2002; Chen, 2005; Hayashida, 2006; Manenti, 2008; Kinoshita, 2008; Ellingson, 2010)  ADC (or mean diffusion) =  cell density (“hypercellularity”)  ADC =  cell density (“hypocellularity”) Viable Tumor (Dark) Necrotic Core Edema ADC Map B.M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011

ADC correlates with brain tumor cell density Untreated glioma patients (WHO II-IV) underwent diagnostic stereotactic biopsy (n = 17) biopsy sites were spatially matched to the pre-operative ADC map R 2 = ; P < ADC Sensitivity = 1.01 x [mm 2 /s]/[nuclei/mm 2 ] From: Ellingson BM et al., J Magn Reson Imaging, 2010 B.M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011

From: Ellingson, JMRI, 2009, In Press The Functional Diffusion Map (fDM) (Moffat, 2005; 2006; Hamstra, 2005; 2008; Ellingson, 2009; 2010; 2011) B.M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011

From: Ellingson, JMRI, 2009, In Press B.M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011 The Functional Diffusion Map (fDM) (Moffat, 2005; 2006; Hamstra, 2005; 2008; Ellingson, 2009; 2010; 2011)

Early Detection of Brain Tumor Growth T1+C FLAIR fDMs Contrast-Enhancement (white) B.M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011

fDMs in Brain Tumor Progression T1+C FLAIR fDM 3 mo.6 mo.9 mo. (Onset of symptoms) B.M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011

From: Ellingson, ISMRM, 2009; SNO, 2009 fDMs in Progressive Disease (PD)  Hypercellularity B.M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011

From: Ellingson, ISMRM, 2009; SNO, 2009 fDM Results in Stable/Responding Disease (SD/RD)  Hypocellularity B.M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011

From: Ellingson, ISMRM, 2009; SNO, 2009 fDMs May Reflect Molecular/Genetic Phenotypes MGMT(+) MGMT(-) B.M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011

From: Ellingson, ISMRM, 2009; SNO, 2009 fDMs May Reflect Molecular/Genetic Phenotypes B.M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011

(n = 50 Total Patients) Spearman Corr. Coeff. R = , P = Clinical fDM Sensitivity/Specificity WHO Grade From: Ellingson BM et al., ISMRM, 2010 B.M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011

(n = 50 Total Patients) Pearson Corr. Coeff. R 2 = , P < Clinical fDM Sensitivity/Specificity Neurological Status From: Ellingson BM et al., ISMRM, 2010 B.M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011

fDMs Before/After Radiotherapy N = 94

B.M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011 fDMs Before/After Bevacizumab N = 77

Graded fDMs B.M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011

Graded fDMs: Tumor Invasion Beyond FLAIR B.M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011

Graded fDMs for StealthStation™ Biopsy Localization B.M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011

Hypercellular Hypocellular Macrophages & Inflammatory Cells Demyelination Graded fDMs in Differential Diagnosis Tumor vs. Demyelination Biopsy Diagnosis = Demyelination (Multiple Sclerosis) B.M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011

Graded fDMs – Radiation Necrosis Hypercellular Hypocellular T1+C FLAIR Graded fDM B.M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011

Stereotactic fDMs Using a Neuroanatomical Atlas Anatomy Label Map Overlaid On T1 Atlas B.M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011