Chem 509 Signal Transduction Winter 2010 Lecture 4 Comparative genome hybridization, bisulfite modification and the vision system.

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Presentation transcript:

Chem 509 Signal Transduction Winter 2010 Lecture 4 Comparative genome hybridization, bisulfite modification and the vision system

CGHA AKA Comparative Genome Hybridization Weiss et al., 1999

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Weiss et al., 1999

3’AAATAGCAA 5’ATTTTATGG 3’AAATAACAA 5’ATTTTATGG

Proc Natl Acad Sci U S A September 3; 93(18): 9821–9826. Boldface: Differences between modified primers and unmodified primers. Differences between methylated/modified and unmethylated/modified are underlined.

S. Ramón y CajalS. Ramón y Cajal, Structure of the Mammalian Retina, 1900Mammalian