Urokinase Plasminogen Activator (uPA) and its Receptor uPAR

The Importance of Cell Movements In Development Early embryogenesis Organ & tissue development Organ & tissue remodeling throughout life In defense & disease Immune responses Wound healing Invasion & metastasis

Figure The Biology of Cancer (© Garland Science 2007) Hepatacyte Growth Factor (HGF) is a Powerful Inducer of Epithelial Cell Motility

Figure 14.23b The Biology of Cancer (© Garland Science 2007) EGF Secreted by Mθs Induces Motility in Breast Carcinoma Cells Recall:

filopodium Rho Family Small G Proteins Play Central Roles in Cell Motility and Invasiness Rac, Cdc42, Rho and their GEFs (eg Tiam1 Rac) are all involved in the orchestration of extension/sensing/contraction and MMP secretion that are involved in the movement of cells across surfaces. A role for Rho proteins is demonstrated by studies of melanoma.

The Lymphatic System

Figure 14.41a The Biology of Cancer (© Garland Science 2007) Metastasis to draining lymph node Draining Lymph Nodes Can be Destinations for Metastatic Cells

Figure The Biology of Cancer (© Garland Science 2007) The ‘Seed and Soil’ Principle – Some Tissues are More Susceptible to Colonization by Particular Tumors Than Others

Figure The Biology of Cancer (© Garland Science 2007)

Figure The Biology of Cancer (© Garland Science 2007) Breast Cancer Tends to be Osteolytic & Prostate Cancer Tends to be Osteoblastic

Figure The Biology of Cancer (© Garland Science 2007) The Osteoblastic Cascade

Table 14.4 The Biology of Cancer (© Garland Science 2007)

Figure 14.50a The Biology of Cancer (© Garland Science 2007) Cytokeratin-free Bone Marrow Augurs Well

Figure 14.51a The Biology of Cancer (© Garland Science 2007) Gene Expression Signatures Show Some Promise as Prognostic Indicators

Instigators & Responders – Implications for Micrometastases McCallister et al., Cell 133:994 (2008)

Figure The Biology of Cancer (© Garland Science 2007)