Introduction: On Banff 2003, Aberdeen, Scotland, and What Robert Burns Would Think! Kim Solez, M.D.

Going to Scotland: A Good Idea! The most registrants we have ever had with many new faces! We hope that you all will join us in the summer of 2005 in Edmonton for the 8th Banff Conference on Allograft Pathology!

Why Banff? Searching for the Muse(s)! For productive discourse, creativity. Doug Wilson will discuss the muses and reflect back on the meeting’s history from 1991 on, on Tuesday the 17th.

Aberdeen - Close to but not Banff!

Future Banff Meetings: 2005: Edmonton, Canada 2007: Edinburgh, Scotland 2009: Banff, Canada

Slide 6 Banff Conferences on Allograft Pathology

Global consensus generation while maintaining intellectual freedom.

Like the mosh pit at a great rock concert. No partner, the ultimate in individuality, dangerous, but when the music is good everyone dances in sync and life is good.

"Possess the right thinking, in this you must never lapse." Splinter - ninja master/talking rat - Teenage Mutant Ninja Turtle movie (1990)

Dr. Racusen is largely responsible for having constructed the exciting program!

Slide 11 Subjects in Aberdeen Banff meeting Updates of Schemas for Diagnosis and Treatment of Allograft Rejection Updates of Schemas for Diagnosis and Treatment of Allograft Rejection Chronic transplant nephropathy Chronic transplant nephropathy Genomics of Rejection Genomics of Rejection Antibody-mediated rejection/C4d Antibody-mediated rejection/C4d Monocyte/Macrophages Monocyte/Macrophages Tolerance/Accomodation/Immunodepletion Tolerance/Accomodation/Immunodepletion Continued Development/Consensus Generation via Internet Communication Continued Development/Consensus Generation via Internet Communication

Many Unique Elements in Banff 2003: EQA slides (UK) First time as official satellite. First time ITN represented. First inclusion of history … and golf! Dr. David Hamilton First Video Legacy interview. Dr. Stewart Cameron

Slide 13 Banff Classification Milestones 1991 First Conference, Heart Represented 1991 First Conference, Heart Represented 1993 First Kidney International paper, Liver start First Kidney International paper, Liver start Integration with CADI - identical scoring. Liver classification Integration with CADI - identical scoring. Liver classification Integration with CCTT classification. Liver classification published Integration with CCTT classification. Liver classification published Second KI paper. Clinical practice guidelines. Implantation biopsies, microwave. Liver chr. reject Second KI paper. Clinical practice guidelines. Implantation biopsies, microwave. Liver chr. reject Classification of antibody-mediated rejection. Regulatory agencies participating. Heart progress Classification of antibody-mediated rejection. Regulatory agencies participating. Heart progress.

Slide 14 Banff Classification Impact 291 publications containing the word “Banff”! 291 publications containing the word “Banff”! 100 publications containing the phrase “Banff Classification”! 100 publications containing the phrase “Banff Classification”!

Slide 15 Banff Classification Key Publications 1993 Solez et al. International standardization of criteria for the histologic diagnosis of renal allograft rejection: the Banff working classification of kidney transplant pathology. Kidney Int Aug;44(2): Solez et al. International standardization of criteria for the histologic diagnosis of renal allograft rejection: the Banff working classification of kidney transplant pathology. Kidney Int Aug;44(2): Banff schema for grading liver allograft rejection: an international consensus document.Hepatology Mar;25(3): Banff schema for grading liver allograft rejection: an international consensus document.Hepatology Mar;25(3): Racusen et al. The Banff 97 working classification of renal allograft pathology. Kidney Int Feb;55(2): Racusen et al. The Banff 97 working classification of renal allograft pathology. Kidney Int Feb;55(2):

Slide 16 Banff Classification Key Publications (cont.) 2001 Demetris et al, Update of the International Banff Schema for Liver Allograft Rejection: working recommendations for the histopathologic staging and reporting of chronic rejection. An International Panel. Hepatology Mar;31(3): Demetris et al, Update of the International Banff Schema for Liver Allograft Rejection: working recommendations for the histopathologic staging and reporting of chronic rejection. An International Panel. Hepatology Mar;31(3): Rodriguez ER; International Society for Heart and Lung Transplantation. The pathology of heart transplant biopsy specimens: revisiting the 1990 ISHLT working formulation. J Heart Lung Transplant Jan;22(1): Rodriguez ER; International Society for Heart and Lung Transplantation. The pathology of heart transplant biopsy specimens: revisiting the 1990 ISHLT working formulation. J Heart Lung Transplant Jan;22(1):3-15.

Slide 17 Banff Classification Key Publications (cont.) 2003 Racusen, Colvin, Solez et al. Antibody- Mediated Rejection Criteria - an Addition to the Banff '97 Classification of Renal Allograft Rejection.Am J Transplant Jun;3(6):

What would Robert Burns have thought of us? He was a strong supporter of internationalism and love in all its senses, including that in moshing and Town Halls! So probably he would have approved!

“A Man’s A Man for a’ That” by Robert Burns Then let us pray that come what may, (As come it will for a’ that) That Sense and Worth, o’er a’ the earth, May bear the gree* and a’ that, For a’ that, a’ a’ that, It’s coming yet for a’ that. That Man to Man, the world o’er, Shall brothers be for a’ that! *gree = be victorious

Hope this presentation has been useful to you even if you do not completely agree! Commander Lock: Not everyone believes what you do, Morpheus. Morpheus: My beliefs do not require them to. from The Matrix Reloaded (Released May 15,2003) Hope this presentation has been useful to you even if you do not completely agree! Commander Lock: Not everyone believes what you do, Morpheus. Morpheus: My beliefs do not require them to. from The Matrix Reloaded (Released May 15,2003)

Drs. Solez and Racusen would like to thank … our sponsors: Fujisawa GmbH Novartis Pharmaceuticals Pfizer Inc. SangStat Medical Corporation Wyeth-Ayerst Pharmaceuticals Olympus Microscopes The National Kidney Foundation, US Drs. Solez and Racusen would like to thank … our sponsors: Fujisawa GmbH Novartis Pharmaceuticals Pfizer Inc. SangStat Medical Corporation Wyeth-Ayerst Pharmaceuticals Olympus Microscopes The National Kidney Foundation, US

Standards/Guidelines leaders: The National Kidney Foundation, US DOQI guidelines (bone latest) NKF cyberNephrology Banff Conferences Standards/Guidelines leaders: The National Kidney Foundation, US DOQI guidelines (bone latest) NKF cyberNephrology Banff Conferences

Drs. Solez and Racusen would like to thank … our co-organizers: Dr. Jake Demetris Dr. Rene Rodriguez Drs. Solez and Racusen would like to thank … our co-organizers: Dr. Jake Demetris Dr. Rene Rodriguez

Drs. Solez and Racusen would like to thank … our hosts: The University of Aberdeen The City of Aberdeen Drs. Solez and Racusen would like to thank … our hosts: The University of Aberdeen The City of Aberdeen

Drs. Solez and Racusen would like to thank … our local organizers: Prof. John Simpson and staff Prof. Andy Rees and staff Drs. Solez and Racusen would like to thank … our local organizers: Prof. John Simpson and staff Prof. Andy Rees and staff

Drs. Solez and Racusen would like to thank … our tour guide: Elma McMenemy

Drs. Solez and Racusen would like to thank … our meeting coordinator: Michele Hales

Please visit the posters! Monday, 16 June :00 - 8:30Poster Viewing - Near Linklater Room 1: :30Poster Viewing - Near Linklater Room Afternoon free for delegates, except for those attending the Liver Sessions

Final housekeeping remarks. Be on time for buses! Book tours today! Leave us your PowerPoint file! We wish you an enjoyable and profitable conference! Come back in 2005, 2007, 2009 etc.!