ChitoHem By: S. S. Kordestani Ph.D. A New Product from ChitoTech wound care manufacturing company August 2008

Advanced Methods of Hemostasis ChitoHem Absorbable Polysaccharide Nano Particles

ChitoHem Absorbable Nano polysaccharide Hemostatic Powder ChitoHem is a hemostatatic powder derived from natural cellulose. It is suitable for arterial and venous bleeding. Nano technology has been used in preparing ChitoHem. What is ChitoHem?

Mechanism of Action WHAT IS HEMOSTASIS? Hemostasis means 'stopping blood flow'. It involves constriction of the injured vessel, formation of a platelet plug, and coagulation. WHAT IS HEMOSTASIS?

Mechanism of Action The machanism of hemostasis of ChitoHem is twofold: Particles are nano and super absorbent they absorbs blood fluids and increase the concentration of blood elements and Procoagulant Factors including:

Procoagulant Factors

Mechanism of Action On the other hand positive charges of ChitoHem attractsnegative charges of blood elements and encourage the fibrin clot and thus blood coagulation.

Features

Platelets, Vascular and Clotting Factors a brief discussion of their function Platelets - small, anuclear cytoplasmic disks. In an unstimulated state, the shape is discoid. Hemostasis - the process in circulation where the blood is maintained fluid in vessels and without major loss in case of injury. Coagulation factors - Components that exist in the circulation and supply the necessary constituents for clot formation. Hemostasis: The property of the circulation where the circulating fluid is maintained within the blood vessels is referred to as hemostasis. The process depends on a delicate and complex interplay of at least 4 systems: vascular, plasma coagulation factors, platelets and fibrinolytic system.

The basic structure is a longitudinal view of a blood vessel The basic structure is a longitudinal view of a blood vessel. It's wall consist of three layers; from the outside in they are collagen represented by small curliques, smooth muscle represented by a zig-zag line, and endothelium represented by a clear area. Outside the vessel on the left side, from top to bottom, are an intact cell, a broken cell and a mast cell. Each can be identified by the presence of a nucleus shown as a shaded circle. The red specks within the intact cell and being released from the broken cell represent cellular contents such as tissue prothrombin activator, TPA. Cells also contain tissue factor here represented as complex of yellow particles. Within the vessel are numerous platelets represented by ovals. The shaded hexagons represent clotting factors. On the right inner vessel surface are three bold arrows that represent compounds that are released into the blood by the endothelium.

Mechanism of coagulation

ChitoHem Absorbs blood fluid

Applications

Other Hemostatic Products Dry Sealant Rapid Deployment Hemostat HemCon QuikClot

QuikClot

QuikClot QuikClot Sport, a consumer version of a product used to save soldiers' lives in Afghanistan and Iraq, just went on sale from Z-Medica Corp., of Wallingford, Conn. It's a porous sack filled with a highly absorbent mineral from lava rocks. You place it on the wound and it pulls the water from the blood, leaving behind clot-forming platelets. The powder is made from tiny plastic beads and potassium salt that react with blood to quickly form an artificial scab.