Summer 2007 Workshop in Biology and Multimedia for High School Teachers

INTRODUCTION TO STEM CELLS SUMMER TEACHER WORKSHOP BETH MICK BELFAST AREA HIGH SCHOOL BELFAST MAINE Life Sciences-HHMI Outreach. Copyright 2006 President and Fellows of Harvard College.

STEM CELL “UNIT” LESSON PLAN –INTRO LECTURE –PLANARIA LAB –WEB SEARCH –3 DAYS - INCLUDE A WEEKEND TO GIVE TIME FOR PLANARIA TO REGENERATE –REMEMBER TO ORDER PLANARIA AHEAD OF TIME OBJECTIVES –WHAT ARE STEM CELLS? –HOW ARE THEY OBTAINED? –HOW CAN THEY BE USED? –VISUALIZE REGENERATION THROUGH PLANARIA LAB

STEM CELL RESEARCH - WHAT IS IT ALL ABOUT? "Image courtesy of NIH resource for stem cell research"

WHAT HAPPENS AFTER MEIOSIS? WHAT DID MEIOSIS PRODUCE?

GAMETES 2N 1N 2N 1N 4 HAPLOID SPERM4 HAPLOID EGGS

WHAT HAPPENS AFTER MEIOSIS? WHAT DID MEIOSIS PRODUCE? WHAT HAPPENS TO GAMETES?

FERTILIZATION Image courtesy of L. De Vos- U.L.B.- Biodic

WHAT HAPPENS AFTER MEIOSIS? WHAT DID MEIOSIS PRODUCE? WHAT HAPPENS TO GAMETES? WHAT’S THE PRODUCT OF FERTILIZATION?

ZYGOTE The fertilized egg

WHAT HAPPENS AFTER MEIOSIS? WHAT DID MEIOSIS PRODUCE? WHAT HAPPENS TO GAMETES? WHAT IS THE PRODUCT OF FERTILIZATION? HOW DOES A ONE CELL ZYGOTE BECOME A HUMAN?

EMBRYOGENESIS Image courtesy of NIH resource for stem cell research Image courtesy of Brad Smith, University of Michigan

SO…..WHAT ARE STEM CELLS? CELLS THAT CAN MAKE MORE OF THEMSELVES CELLS THAT CAN BECOME ALMOST ANY CELL - MULTIPOTENT "Image courtesy of NIH resource for stem cell research" Stem cells

WHERE DO STEM CELLS COME FROM? EMBRYONIC –BLASTOCYST “ADULT” –CORD CELLS –PLACENTA –CHILDREN –ADULTS

EMBRYONIC STEM CELLS Blastocyst "Image courtesy of NIH resource for stem cell research"

EMBRYONIC STEM CELLS ARE OBTAINED FROM INVITRO- FERTILIZATION EMBRYOS THAT WERE NOT USED

“ADULT” STEM CELLS ARE OBTAINED IN A VARIETY OF WAYS Illustration by Matt Bohan, 2007

STEM CELLS HAVE ALSO BEEN FOUND IN “MATURE” ORGANS Illustration by Matt Bohan, 2007

PROS AND CONS OF EACH TYPE EMBRYONIC –CELL LINES LAST AND LAST AND LAST –MULTIPOTENT –EASY TO FIND –ETHICAL ISSUES - WHEN DOES LIFE BEGIN? ADULT –CELL LINES DO NOT LAST –NOT MULTIPOTENT –HARD TO LOCATE –NO ETHICAL ISSUES

ANIMATIONS HOW EMBRYONIC STEM CELL LINES ARE MADE WHAT IS A STEM CELL

REFERENCES on/baefec_01_01.jpghttp:// on/baefec_01_01.jpg