Miki Lee / OEB 192 – 08.11.12 Mobile genetic elements and adaptive mutation.

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Miki Lee / OEB 192 – Mobile genetic elements and adaptive mutation

IS family

Effects on bacterial evolution An important source of genetic variation – Insertion – Homologous recombination

Effects on bacterial evolution

— M-evolved — S-evolved — M+S-evolved — M/S-evolved

Mutation Luria–Delbrück experimentCairns–Foster system

Modified Cairns–Foster system

Kugelberg E. et.al. PNAS 2006;103:

Monday (11/17): Physiological basis of fitness

Upcoming talks Tuesday, 12/16 Rich Lenski Michigan State University 12:30 pm, 341 Warren Alpert (HMS)