Biology 107 Carbon and Molecular Diversity September 1, 2004.

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Presentation transcript:

Biology 107 Carbon and Molecular Diversity September 1, 2004

Carbon Student Objectives:As a result of this lecture and the assigned reading, you should understand the following: 1.Role of carbon in life's diversity - next to water, compounds containing carbon are the most common substances in living organisms. 2.The enormous variety of carbon-based molecules is because a carbon atom has 4 outer shell electrons in a shell that holds 8. 3.Compounds with the same molecular formula but different structure are called isomers.

Carbon 4.The unique properties of an organic compound depend not only on its carbon skeleton, but also on certain groups of atoms that are covalently linked to the skeleton. These groups of atoms are called functional groups, the name reflecting the fact that these parts of the organic molecules usually are involved in chemical reactions. See Table 4.1 in Campbell and Reece. 5.Most of these functional groups are polar, because their oxygen or nitrogen atoms are highly electronegative. The polarity tends to make compounds containing these groups hydrophilic, and therefore soluble in water - a necessary condition for their roles in water-based life. Note that many biological molecules have two or more functional groups (e.g., amino acids - contain at least one carboxyl as well as one amino group).

Carbon 6.Organic macromolecules are polymers created through dehydration synthesis reactions that chemically link the specific monomers together with covalent bonds. Polymers are broken down through hydrolysis reactions. 7.It is the variety in polymers that accounts for the uniqueness of each organism; the monomers used to make polymers are essentially universal throughout the biological realm.

Types of Bonds IntramolecularIntermolecular CovalentHydrogen Ionic Van der Waals Metallic Ionic Attractions

Examples of Bond Strengths Bond Type Bond Length (nm) Bond Strength in Water (kcal/mole) Covalent Ionic0.253 Hydrogen0.301 Van der Waals (per atom)

Organic Molecules Contain Carbon

Valence Shells of Atoms Most Commonly Found in Organic Molecules

Majors Types of Isomers 1.Structural isomers (different covalent arrangements) 2.Geometric isomers (differ around double bond) 3.Enantiomers (mirror-images that differ around an asymmetric, chiral, atom)

What is Chirality? Immanuel Kant, 1783 “The glove of one hand cannot be used on the other” (R) “rectus” RIGHT RIGHT (S) “sinister” LEFT LEFT

ENANTIOMERS Enantiomers have identical physical and chemical properties. EXCEPT Ability to rotate the plane of polarized light and Rate of reaction and interaction with other chiral compounds and environments

Importance of Chirality Different activities? Same activity different potency

CHIRALITY AND DRUG ACTION Why do enantiomers have the potential for exhibiting different pharmacodynamic and/or pharmacokinetic properties?

Primary Functional Groups

C O-H Functional Groups 1. Hydroxyl C C O H 2. Carbonyl C C C O aldehyde ketone

C O O H C C O O-O- C 3. Carboxyl Functional Groups C N H H N H H H C + H + 4. Amino +

P O H O O C P O-O- O-O- O O C + 2 H + 6. Phosphate Functional Groups 5. Sulfhydral C S-H

Slight Differences in Functional Groups May Have Dramatic Functional Effects

Biological Molecules Usually Have More Than One Functional Group

Dehydration Synthesis Reactions - Additions

Hydrolysis Reaction - Removals

Polymer Synthesis and Breakdown Reactions Synthesis of complex molecules from simpler molecules (anabolism) by dehydration synthesis reactions Break down of complex molecules to simpler molecules (catabolism) by hydrolysis reactions Why so many different metabolic enzymes in cells?