Chapter 14 Alcohols, Phenols, Ethers, and Thiols

Slides:



Advertisements
Similar presentations
1 3.9 Reactions of alcohols 1.Combustion 2. Dehydration 3. Formation of ethers 4.Oxidation.
Advertisements

Chapter 17: Organic Chemistry
Properties of Aldehydes and Ketones Chapter 13 Organic Compounds with oxygen and Sulfur.
Chemistry: An Introduction to General, Organic, and Biological Chemistry, Twelfth Edition© 2015 Pearson Education, Inc Reactions of Alcohols, Thiols,
Chapter 12 Organic Compounds with Oxygen and Sulfur
Organic I Prof. Dr. Abdellatif M. Salaheldin Chemistry Department
Chapter 12 Organic Compounds with Oxygen and Sulfur
Alcohols, Ethers and Thiols Bettelheim, Brown, Campbell and Farrell Chapter 14.
Organic Chemistry II CHEM 271. Chapter One Alcohols, Diols and Thiols.
LecturePLUS Timberlake1 Chapter 12 Alcohols, Phenols, Ethers, Aldehydes, and Ketones Alcohols, Phenols, and Thiols Ethers Reactions of Alcohols.
What are alcohols? An alcohol contains a hydroxyl group (—OH) attached to a carbon chain. A phenol contains a hydroxyl group (—OH) attached to a benzene.
1 National 5 Chemistry Alcohols. 2 An alcohol contains  A hydroxyl group (—OH) attached to a carbon chain.
Chemistry: An Introduction to General, Organic, and Biological Chemistry, Eleventh Edition Copyright © 2012 by Pearson Education, Inc. Chapter 12 Organic.
1 Chapter 13 Organic Compounds with Oxygen and Sulfur 13.3 Reactions of Alcohols and Thiols Copyright © 2005 by Pearson Education, Inc. Publishing as Benjamin.
1 Announcements & Agenda (03/12/07) Pick Up Quizzes Exam THIS Wednesday! Covers Ch 7, 8, (not 12.6, on Exam 3) Covers Ch 7, 8, (not 12.6, on.
Chapter 13 Alcohols, Phenols, and Thiols
Timberlake LesturePLUS Chapter 12 Alcohols, Phenols, Ethers, Aldehydes, and Ketones Oxidation and Reduction.
Chapter 15 Aldehydes and Ketones
Properties of Alcohols, Ethers, and Thiols Chapter 12 Organic Compounds with Oxygen and Sulfur Copyright © 2005 by Pearson Education, Inc. Publishing.
Alcohols, Phenols, and Thiols
Alcohols IB Chemistry Topic Alcohols Asmt. Stmts Describe, using equations, the complete combustion of alcohols Describe, using.
Chemistry 2100 Chapter 14.
4.1 Systematic Nomenclature 1. Definitions Molecular formula Number of atoms in a molecule (element or compound) e.g. C 2 H 4 O 2 Empirical formula Simplest.
Alcohols, Phenols, Ethers, Aldehydes, and Ketones Alcohols, Phenols, and Thiols Ethers Reactions of Alcohols.
Ch. 14 Alcohols, Phenols, and Ethers Milbank High School.
Chapter 8 Alcohols, Ehters and Thiols. Hydroxyl (OH) functional group Oxygen is sp 3 hybridized.
CHAPTER 13 CONCURRENT ENROLLMENT. ALCOHOL Alcohol –A–A–A–A compound in which an -OH group is connected to an aliphatic carbon atom CH3-CH2-OH ethanol.
Chapter 13 Alcohols, Phenols, and Ethers Spencer L. Seager Michael R. Slabaugh Jennifer P. Harris.
TYPES OF ORGANIC CHEMICAL REACTIONS
Functional Group Reactions Organic Chemistry Lesson # 4.
Chapter 9 Aldehydes and Ketones Chemistry 20. Carbonyl group C = O Aldehydes Ketones Carboxylic acids Esters.
UNIT 4: Alcohols, Phenols and Ethers
Alcohols, Ethers, Thiols and Chirality
Chapter 14: Alcohols, Ethers, and Thiols Alcohol:OH(hydroxyl) group Alcohol: A compound that contains an -OH (hydroxyl) group bonded to a tetrahedral carbon.
Alcohols L Scheffler. An alcohol consists of a carbon chain with a hydroxy group (-OH) attached Alcohols Methanol Ethanol Propanol Phenol.
LecturePLUS Timberlake1 Alcohols, Phenols, Ethers, Aldehydes, and Ketones Alcohols, Phenols, and Thiols Ethers Reactions of Alcohols.
Alcohols, Ethers, and Thiols
Chapter 5 Alcohols, Ethers, and Thiols. Alcohols Alcohol:OH(hydroxyl) group Alcohol: A compound that contains an -OH (hydroxyl) group bonded to a tetrahedral.
© 2003 Thomson Learning, Inc. All rights reserved General, Organic, and Biochemistry, 7e Bettelheim, Brown, and March.
What is combustion? Write a definition Write an equation of combustion for the following alcohols: Ethanol Methanol Propanol.
IMPORTANT ALCOHOLS Methanol (wood alcohol): CH 3 OH Production: Useful as a solvent and industrial starting material Highly toxic, if taken internally.
Alcohols, Ethers, Thiols and Chirality
LecturePLUS Timberlake1 Chapter Organic Chemistry: Alcohols, Phenols, Ethers, Aldehydes, and Ketones Alcohols, Phenols, and Thiols Ethers Reactions of.
1 Lecture 4 Alcohols, Phenols, and Thiols Alcohols, Phenols, and Thiols Copyright © 2007 by Pearson Education, Inc. Publishing as Benjamin Cummings.
13-1 Principles and Applications of Inorganic, Organic, and Biological Chemistry Denniston, Topping, and Caret 4 th ed Chapter 13 Copyright © The McGraw-Hill.
Chapter 13 Alcohols, Phenols, and Thiols
(D) The Chemistry of Cooking and the Oxidation of Food
Alcohols IB Chemistry Topic 10.4.
Chapter 13: Alcohols, Phenols, and Ethers
Chemistry: An Introduction to General, Organic, and Biological Chemistry, Eleventh Edition Copyright © 2012 by Pearson Education, Inc. Chapter 12 Organic.
Alcohols Alcohols Contain a hydroxyl group (-OH).
1 Chapter 13: Alcohols, Phenols, and Ethers. 2 ALCOHOLS, PHENOLS, AND ETHERS Hydroxy group – the –OH functional group An alcohol has an –OH group attached.
Chapter 13 Alcohols, Phenols, and Ethers Spencer L. Seager Michael R. Slabaugh Jennifer P. Harris.
Leaving Certificate Chemistry
Goals for the Day: Reactions of Alcohols Zaitsev’s Rule Substitution of double bonds Oxidation/Reduction.
Chapter 1.4 Alcohols, Ethers, and Thiols
General, Organic, and Biochemistry, 8e
13.4 Reactions of Alcohols and Thiols
Alcohols.
Chapter 14 Alcohols, Phenols, Ethers, and Thiols
Oxidation and Reduction
Chapter 13 Alcohols, Phenols, and Thiols
Chapter 13: Alcohols, Phenols, and Ethers
1.5 ALDEHYDES AND KETONES.
Alcohols, Ethers and Thiols
Alcohols IB Chemistry Topic 10.
Chapter 13 Alcohols, Phenols, and Thiols
Alcohols, Ethers, and Thiols
Alcohols, Phenols, and Thiols
Chapter 12 Alcohols, Phenols, Ethers, Aldehydes, and Ketones
Presentation transcript:

Chapter 14 Alcohols, Phenols, Ethers, and Thiols 14.5 Physical Properties of Alcohols, Phenols, and Ethers 14.6 Reactions of Alcohols

Boiling Points of Alcohols Alcohols contain a strongly electronegative O in the OH groups. Thus, hydrogen bonds form between alcohol molecules. Hydrogen bonds contribute to higher boiling points for alcohols compared to alkanes and ethers of similar mass.

Boiling Points of Ethers Ethers have an O atom, but there is no H attached. Thus, hydrogen bonds cannot form between ether molecules.

Solubility of Alcohols and Ethers in Water Alcohols and ethers are more soluble in water than alkanes because the oxygen atom can hydrogen bond with water. Alcohols with 1-4 C atoms are soluble, but alcohols with 5 or more C atoms are not.

Reactions of Alcohols Alcohols undergo combustion with O2 to produce CO2 and H2O. 2CH3OH + 3O2 2CO2 + 4H2O + Heat Dehydration removes H- and -OH from adjacent carbon atoms by heating with an acid catalyst. H OH | | H+, heat H—C—C—H H—C=C—H + H2O | | | | H H H H alcohol alkene

Formation of Ethers Ethers form when dehydration takes place at low temperature. H+ CH3—OH + HO—CH3 CH3—O—CH3 + H2O Two Methanol Dimethyl ether

Oxidation and Reduction In organic chemistry, oxidation is a loss of hydrogen atoms or a gain of oxygen. In an oxidation, there is an increase in the number of C-O bonds. Reduction is a gain of hydrogen or a loss of oxygen. The number of C-O bonds decreases.

Oxidation of Primary Alcohols In the oxidation [O] of a primary alcohol, one H is lost from the –OH and another H from the carbon bonded to the OH. [O] Primary alcohol Aldehyde OH O | [O] || CH3—C—H CH3—C—H + H2O | H Ethanol Ethanal (ethyl alcohol) (acetaldehyde)

Oxidation of Secondary Alcohols The oxidation of a secondary alcohol removes one H from –OH and another H from the carbon bonded to the –OH. [O] Secondary alcohol Ketone OH O | [O] || CH3—C—CH3 CH3—C—CH3 + H2O | H 2-Propanol Propanone (Isopropyl alcohol) (Dimethylketone; Acetone)

Oxidation of Tertiary Alcohols Tertiary alcohols are resistant to oxidation. [O] Tertiary alcohols no reaction OH | [O] CH3—C—CH3 no product | CH3 no H on the C-OH to oxidize 2-Methyl-2-propanol

Ethanol CH3CH2OH Ethanol: Acts as a depressant. Kills or disables more people than any other drug. Is metabolized at a rate of 12-15 mg/dL per hour by a social drinker. Is metabolized at a rate of 30 mg/dL per hour by an alcoholic.

Oxidation of Alcohol in the Body Enzymes in the liver oxidize ethanol. The aldehyde produced impairs coordination. A blood alcohol level over 0.4% can be fatal. O || CH3CH2OH CH3CH 2CO2 + H2O Ethyl alcohol acetaldehyde

Oxidation of alcohols in liver

Effect of Alcohol on the Body

Breathalyzer test K2Cr2O7 (potassium dichromate) This orange colored solution is used in the Breathalyzer test (test for blood alcohol level) Potassium dichromate changes color when it is reduced by alcohol K2Cr2O7 oxidizes the alcohol

Breathalyzer reaction orange-red green 8H++Cr2O72-+3C2H5OH→2Cr3++3C2H4O+7H2O dichromate ethyl chromium (III) acetaldehyde ion alcohol ion (from K2Cr2O7)

Alcohol Contents in Common Products % Ethanol Product 50% Whiskey, rum, brandy 40% Flavoring extracts 15-25% Listerine, Nyquil, Scope 12% Wine, Dristan, Cepacol 3-9% Beer, Lavoris

The proof of an alcohol The proof of an alcoholic beverage is merely twice the percentage of alcohol by volume. The term has its origin in an old seventeenth-century English method for testing whiskey. Dealers were often tempted to increase profits by adding water to booze. A qualitative method for testing the whiskey was to pour some of it on gunpowder and ignite it. If the gunpowder ignited after the alcohol had burned away, this was considered “proof” that the whiskey did not contain too much water.

Production of ethanol from grain by fermentation Grain seeds are grounded and cooked → mash Malt (the dried sprouts of barley) or special mold is added → source of the enzyme diastase that catalyzes the conversion of starch to malt sugar, maltose diastase (C6H10O5)2x + H2O → x C12H22O11 starch maltose Pure yeast culture is added C12H22O11 + H2O → 2 C6H12O6 maltose glucose C6H12O6 → 2 CH3CH2OH + 2 CO2 glucose ethanol carbon dioxide

Preparation of alcohols Ethanol is made by hydration of ethylene (ethene) in the presence of acid catalyst

Isopropyl is produced by addition of water to propylene (1-propene)

Methanol is made commercially from carbon monoxide and hydrogen CO + 2H2 → CH3OH

Oxidation of Thiols. Mild oxidizing agens remove two hydrogen atoms from two thiol molecules. The remaining pieces of thiols combine to form a new molecule, disulfide, with a covalent bond between two sulfur atoms. R – S – H H – S – R+I2 → RS – SR+2HI 2 RSH + H2O2 → RS – SR + 2 H2O

The chemistry of the “permanent” waving of hair. Hair is protein, and it is held in shape by disulfide linkages between adjacent protein chains. The first step involves the use of lotion containing a reducing agent such as thioglycolic acid, HS – CH2 – COOH. The wave lotion ruptures the disulfide linkages of the hair protein. The hair is then set on curles or rollers and is treated with a mild oxidizing agent such as hydrogen peroxide (H2O2). Disulfide linkages are formed in new positions to give new shape to the hair. Exactly the same chemical process can be used to straighten naturally curly hair. The change in hair style depends only on how one arranges the hair after the disulfide bonds have been reduced and before the reoxidation takes place. Permanent Hair Wave (http://www.elmhurst.edu/~chm/vchembook/568hairwave.html)