Chem 509 Signal Transduction Winter 2010 Lecture 2.

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Presentation transcript:

Chem 509 Signal Transduction Winter 2010 Lecture 2

What difference between Gs, Gq and Gi?: 1.Gs, G protein that is stimulatory and binds AC 2.Gq, G protein that is stimulatory and binds PLC 3.Gi, G protein that is inhibitory and binds AC.

Phosphatidylinositol Phosphatidylinositol- diphosphate

Phospholipases Phospholipase A1-can hydrolyse the sn-1 acyl bond but can also hydrolyse the sn-2 acyl bond. In the former case, this liberates a fatty acid and 2-acyl-glycerophospholipid.

Phospholipases Phospholipase A2-hydrolyses the sn-2 acyl bond. This liberates a fatty acid and a lysophospholipid (1-acyl-glycerophospholipid)

Phospholipases Phospholipase C-hydrolizes one phosphoester bond to generate diacyglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3).

Phospholipases Phospholipase D-will hydrolyse the other phosphoester bond to generate phosphatidic acid (amphiphilic product) and inositol 4,5 diphosphate (IP2).

PI=Phosphatidylinositol, Phosphorylated derivatives of PI are denoted as PIPx. PC=Phosphatidylcholine PA=Phosphatidic acid Lyso PC= deacylated phosphatidylcholine

Calmodulin

End of GPCR lecture story

Insulin signaling

Other Receptor Tyrosine Kinase Receptors

Cross talk (part of integration of signals)

Brief overview of cancer signaling pathways

Cell cycle