Do oligomers damage membranes?. Oligomers bind to vesicle membranes (in vitro incubation with ex-vivo or artificial lipids) Brain derived lipids Phosphatidylglycerol.

Slides:



Advertisements
Similar presentations
Sporadic AD familial AD etiology environmental factors, genetic predisposition etiology oligomerization of A 42 and initial (diffuse) A 42 deposits subtle.
Advertisements

Parkinson’s disease: February 19th BIOS E108 Parkin and PINK1
Mechanisms of Bcl-2 in Programmed Cell Death Laura Beth Hill St. Edward’s University.
Of neurotoxicity and α-synuclein Richard Wilson Clayton DF & George JM (1999) J Neurosci Res 58, 120–129.
Sara Herrera Advisor: Shubhik K. DebBurman Department of Biology Lake Forest College New  -Synuclein Mutants: How Do They Contribute To Parkinson’s Disease?
MECHANISMS OF AGING TheoryPrinciples DNA & Genetic Theory Aging is predetermined by genetic programming. Neuroendocrine Theory Loss of hypothalamic regulation.
Α-Synuclein Interaction with Phospholipids: Possible Implications for Parkinson’s Disease Literature Seminar by Jessica L. Anderson.
Huntington’s disease Also called Huntington Chorea, affects men and women. 4 to 10 cases in 100,000 people (frequency between 0.004% and 0.01%) . Chorea.
September 13th BIOS E108 Parkinson’s disease (PD) -Pathology -Diagnosis -  -synuclein.
Parkinson’s Disease Pathology 430/826 The Molecular Basis of Disease Neurological Genetics 9 th March 2015 Dr. John Rossiter
Lewy Bodies in PD. Lewy Body Inclusions and the effect of coffee and decaffeinated extracts on Drosophila neuronal cultures.
THE NEW APPROACH. Introduction For a long period of time it was state of the art to design drugs displaying one defined pharmacological mode of action.
February 12th BIOS E108 Parkinson’s disease (PD) -Pathology -Diagnosis -  -synuclein.
THE NERVOUS SYSTEM. Brain WHAT PARTS DO YOU KNOW THAT ARE IN THE NERVOUS SYSTEM? Spinal Cord Peripheral Nerves.
Neuroprotective Effects of Memantine. Hippocampal slice cultures Brown et al., Soc. Neurosci 2003 Semi-chronic 3-NP toxicity in organotypic hippocampal.
Α-synuclein, Lewy Bodies, Prions, and Parkinson’s Disease Cody McCullough & Sara Homsi BCM 465 April 19 th, 2010.
Rôle des dysfonctions mitochondriales et lysosomales dans la maladie de Parkinson Jean-Christophe (Chris) Rochet UER Neurohistologie-Neuropathologie Department.
PATHOLOGIC AGGREGATION OF THE BRAIN PROTEIN  -SYNUCLEIN CAUSES CELL DEATH IN PARKINSON AND ALZHEIMER DISEASE, Wenbo Zhou, PhD and Curt R. Freed, MD Division.
 Maintain internal homeostasis.  Regulate body temperature  Maintain tissue and cellular pH.
Cell death in PD: the case for mitochondria. Background defects in the capacity of the ubiquitin-proteasome system (UPS) to degrade unwanted proteins.
Mitochondrial function in Cell death in PD. Pathology Loss of SN pigmented dopamine neurons Lewy bodies Lewy neurites-multiple brain regions Lewy bodies.
Under the supervision of miklós jászberényi
By: London Seigle & Marlinda Reakes. Structure of Cytoskeleton  Long, twisted strands (criss-crossing)  A cellular, scaffolding structure  Found within.
DNA Replication Replication is semi-conservative (one strand is old, one strand new)
Figure 3 Purpose: To further characterize cell-to-cell transmission of α- synuclein using an in vitro coculture model Figure 3(A) Hypothesis: If myc-tagged.
Neuroprotective Effects of Memantine. Hippocampal slice cultures Brown et al., Soc. Neurosci 2003 Semi-chronic 3-NP toxicity in organotypic hippocampal.
Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death by Alejandro Martorell ‐ Riera, Marc Segarra ‐ Mondejar,
Neurotoxic Effects of Salsolinol Jung Hoon Kang Department of Genetic Engineering Cheongju University.
Airborne particulate pollution as a potential environmental risk factor for Alzheimer's disease Professor David Allsop, Faculty of Health and Medicine,
Preston Ge Institute for Cell Engineering
Protein conformational disorders
Potential mechanisms of drug-induced liver injury
Protein conformational disorders
Advisor: Shubhik K. DebBurman Department of Biology
Cellular responses to stress (Adaptations, injury and death) (3 of 5)
III. Parkinson Disease.
S Braun, N Gaza, R Werdehausen, H Hermanns, I Bauer, M. E. Durieux, M
Reversing Neurodegeneration:A Promise Unfolds
Inhibition of alpha-synuclein using promazine derivatives
Understanding the structure of a protein involved in Parkinson’s disease -My research proposal was “Relating the structure of aggregated alpha synuclein.
Understanding the structure of a protein involved in Parkinson’s disease -My research proposal was “Relating the structure of aggregated alpha synuclein.
Michael V. Berridge, Remy T. Schneider, Melanie J. McConnell 
New Animal Models for Parkinson's Disease
The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis
Volume 96, Issue 10, Pages (May 2009)
α-Synuclein – Regulator of Exocytosis, Endocytosis, or Both?
Journal Club 19th Feb years ago cis, binding trans, not-binding 1.
Vimlesh Kumar, Mani Ramaswami  Neuron 
STP2 & GAPDH: Partners in crime towards -Synuclein Toxicity
α-Synuclein and Tau: Mitochondrial Kill Switches
Parkinson's Disease Neuron
Amyloid Polymorphism: Structural Basis and Neurobiological Relevance
Figure 1 Key events in the pathophysiological cascade of MSA
Volume 23, Issue 12, Pages (June 2018)
Mechanisms Underlying Inflammation in Neurodegeneration
Volume 14, Issue 2, Pages (February 2008)
Vimlesh Kumar, Mani Ramaswami  Neuron 
Volume 22, Issue 1, Pages (January 2018)
Volume 10, Issue 3, Pages (September 2002)
Genetic Animal Models of Parkinson's Disease
Alzheimer Mechanisms and Therapeutic Strategies
The Function of α-Synuclein
Understanding Dopaminergic Cell Death Pathways in Parkinson Disease
In Vitro Analysis of Huntingtin-Mediated Transcriptional Repression Reveals Multiple Transcription Factor Targets  Weiguo Zhai, Hyunkyung Jeong, Libin.
SNX2 is capable of sensing membrane curvature but does not induce membrane tubulation in vitro or in vivo. SNX2 is capable of sensing membrane curvature.
Peptide-membrane Interactions: Peptide Insertion
Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method by Francesco A. Aprile,
A Proposed Mechanism for Neurodegeneration in Movement Disorders Characterized by Metal Dyshomeostasis and Oxidative Stress  Benjamin Guy Trist, Dominic.
Volume 85, Issue 1, Pages (January 2015)
Design of lipid-binding deficient mutants of α-synuclein.
Presentation transcript:

Do oligomers damage membranes?

Oligomers bind to vesicle membranes (in vitro incubation with ex-vivo or artificial lipids) Brain derived lipids Phosphatidylglycerol

E57K mutant promotes the formation of ring-like structures (in vitro incubation with lipid monolayer)

Disrupting the organization between  -helix and  -sheet strands improves the formation of oligomers versus fibrils, making the  -synuclein more toxic

Can  -synuclein oligomers cause mitochondrial damage in PD?

Overexpression of  -syn induces mitochondrial fragmentation

 -syn dependent mitochondrial fragmentation precedes mitochondrial dysfunction…

…and neuronal death

 -syn disrupts intramitochondrial structure in vitro and…

Feedback: Privacy Policy Feedback
Do Not Sell My Personal Information
About project: SlidePlayer Terms of Service

© 2025 SlidePlayer.com. Inc. All rights reserved.