Auditory Transduction How the ear converts acoustic energy into a neural response.

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Presentation transcript:

Auditory Transduction How the ear converts acoustic energy into a neural response

The bottom line Hair cells are specialized so that motion of their stereocilia changes their electrical potential, resulting in neurotransmitter release and action potentials in the nerve fibers that contact the hair cells.

A closer look at the organ of Corti From Pickles (1992)

The solid barrier between the hair cell bodies and the stereocilia is the (A) Reissner’s membrane (B) basilar membrane (C) helicotrema (D) reticular lamina 4 4

Reticular lamina From Gelfand (1998), Lim (1986)

Electrical situation in the organ of Corti From Gelfand (1998)

If there is a positive potential difference between the endolymph and the inside of the hair cells, electrical currents will tend to flow (A) into the hair cells (B) out of the hair cells (C) into the stria vascularis (D) across Reissner’s membrane 7 7

Another view... From Gelfand (1998)

Basilar membrane motion From Pickles (1992)

Cochlear motion

The motion of the basilar membrane is similar to the motion (A) of a sine wave (B) of a triangular wave (C) of a rope that is “flicked” at one end 11

If I play a tone into the ear, the motion of the basilar membrane will be most like (A) a sine wave. (B) a triangular wave. (C) a rope alternately “flicked” up and down. 12

“shearing action” From Gelfand (1998)

“shearing action” movie

Inner hair cell stereocilia

Shearing of the tectorial membrane across the reticular lamina displaces the (A) stereocilia (B) basilar membrane (C) Deiter’s cells (D) pillar cells 16

Stereocilia From Schneider et al. (2002)

IHC excitation probelft.mov

IHC inhibition probergh.mov

Stereocilia motion From Gelfand (1998)

Neural response phaslock.mov

Positive pressure ________ the hair cells; negative pressure _______ the hair cells. (A) excites; excites (B) excites; inhibits (C) inhibits; excites (D) inhibits; inhibits 22

Tip links From Gelfand (1998)

Opening transduction channels From Gelfand (1998)

Transduction channels From Gelfand (1998)

Positive pressure _________ the tip links; negative pressure _______ the tip links (A) stretches; stretches (B) stretches; compresses (C) compresses; stretches (D) compresses; compresses 26

Receptor potential From Gelfand (1998)

As the sound pressure increases (A) the amplitude of basilar membrane motion increases. (B) the displacement of the stereocilia increases. (C) the tip links are stretched more. (D) more ions flow into the hair cell. (E) all of the above. 28

If more ions flow into the hair cell (A) the neurons contacting the hair cell will respond more. (B) the neurons contacting the hair cell wil respond less. 29

Neural response rate From Pickles (1992)

If I play a tone into the ear, action potentials in the neurons contacting a hair cell (A) will tend to occur at the negative phase of the sound wave. (B) will tend to occur at the positive phase of the sound wave. (C) will occur equally often at all phases of the sound wave. 31

Neural response phaslock.mov

Conclusions The stria vascularis maintains a potential difference between the tops and bottoms of hair cells. When the basilar membrane is set into motion, the tectorial membrane shears across the hair cell stereocilia. When the stereocilia are pushed “out”, the tip links are stretched, opening ion channels in the stereocilia tips that allow ions to flow into the hair cell.

Conclusions (continued) This electrical change results in neurotransmitter release and a response in the auditory nerve fibers contacting the hair cell.

Text sources Gelfand, S.A. (1998) Hearing: An introduction to psychological and physiological acoustics. New York: Marcel Dekker. Pickles, J.O. (1988) An introduction to the physiology of hearing. Berkeley: Academic Press. Schneider, M.E., Belyantseva, I.A., Azevedo, R.B. & Kachar, B. (2002) Structural cell biology: Rapid renewal of auditory hair bundles. Nature, 418: