AHA STEP I DIET IMPROVES THE LIPOPROTEIN PROFILE OF HYPERCHOLESTEROLEMIC MEN Oslo Study. Am J Med 66:105, * 341 VLDL LDL HDL * 50* * >6.1 >3.7 * FIG 1

FATTY ACID BALANCE IMPROVES THE LDL/HDL RATIO IN NORMOLIPEMIC HUMANS FATTY ACID BALANCE IMPROVES THE LDL/HDL RATIO IN NORMOLIPEMIC HUMANS VLDL LDL HDL * Sundram et al. J.Nutr.Biochem. 6:179,1995 >2.2 >1.7* > > 2.0 FIG 2

LP PROFILE IN WOMEN AT HIGH vs. LOW FAT INTAKE AND 0.3 vs. 1.0 P/S RATIO VLDL LDL HDL Jones et al AJCN 45:1451,1987 >2.4>2.1>1.8* * * 55 > 2.6 I III FIG 3

IMPROVED LIPOPROTEIN PROFILE AFTER BALANCING THE DIETARY S:M:P RATIO Schwandt et al. ATHERO 44:9, * 204 VLDL LDL HDL * 43 >2.8* >3.3 FIG 4

LIPOPROTEIN PROFILE AFTER HIGH vs. MOD FAT INTAKE AT TWO P/S RATIOS * 199 Weisweiler et al. METAB 34:83,1985 VLDL LDL HDL * >3.3>2.8 * >3.0 FIG 5

390 Schaefer et al. AJCN 34:1758, * 127 ** 347* VLDL LDL HDL 291** * 38* 82 31** ** 285* >7.9 >8.4 Normolipemics Hyperlipemics >7.5 >2.4 >2.6 LP PROFILE IN NORMO- v HYPERLIPEMIC SUBJECTS AT HIGH v LOW P/S RATIOS FIG 6

LIPOPROTEIN RESPONSE TO BALANCED FA INTAKE IN NORMOLIPEMIC MEN LIPOPROTEIN RESPONSE TO BALANCED FA INTAKE IN NORMOLIPEMIC MEN Nelson et al LIPIDS 30: 969, VLDL LDL HDL > > 2..8 > FIG. 7

HUMAN LIPOPROTEIN RESPONSE TO LOW-MUFA OR HIGH-MUFA DIETS HUMAN LIPOPROTEIN RESPONSE TO LOW-MUFA OR HIGH-MUFA DIETS Chang JLR 31:2141, VLDL LDL HDL * 50 >1.80* >1.55 n=8 crossover FIG. 8

CYNO MONKEY RESPONSE TO DIETARY FA BALANCE (with 0.05% cholesterol) Hayes, unpublished data VLDL LDL HDL >1.8 >1.3*> > 1.3* 35%en 13:16:6 P/S %en 9:11:10 P/S %en 9:13:8 P/S %en 4:23:3 P/S 0.8 FIG 9

HUMAN LIPOPROTEIN RESPONSE TO STEPWISE REMOVAL OF SFA ( DELTA 1 ) Mustad et JLR 38:459, VLDL LDL HDL >2.8 > > %en 15:13:6 P/S %en 9:13:6 P/S %en 6:13:6 P/S 1.0 * * FIG 10

SFA and PUFA balance enhances the LDL/HDL RATIO and 16:0+18:0 are better than 12:0+14:0 in CEBUS MONKEYS ** AADAHA-1AHA-2AHA-16:0AHA-14:0 VLDL LDL HDL Pronczuk et al. FASEB J 6:A561, * 167*168* * * >0.78 >0.72 >0.65 >0.57* 35%en 13:18:6 P/S %en 10:10:10 P/S %en 5:10:10 P/S %en 8:8:8 P/S 1.0 Plasma cholesterol (mg/dl) 25%en 8:8:8 P/S 1.0 > * * Fig 11

COMPARISON BETWEEN cis 18:1, 16:0, 12:0+14:0, AND trans 18:1 IN NORMOLIPEMIC HUMANS * VLDL LDL HDL Sundram et al. J.Nutr.127:514s,1997 >2.6 >3.7* * 139* 149* > 3.1* 41* 46 cis 18:1 32%EN 10:17:5 P/S :0 32%EN 14:14:4 P/S :0 33%EN 17:10:5 P/S 0.4 trans 18:1 31%EN 7:11+7:6 P/S 0.8 Fig 12