Electron Transport Chain (ETC) and Oxidative Phosphorylation (Ox Phos)

Slides:

Advertisements

Similar presentations

Biochemistry Lecture 12.

Advertisements

Electron Transport and ATP Synthesis C483 Spring 2013.

Chapter 14 - Electron Transport and Oxidative Phosphorylation The cheetah, whose capacity for aerobic metabolism makes it one of the fastest animals.

Chemiosmotic theory of oxidative phosphorylation

Overview of oxidative phosphorylation

Electron Transport Chain/Respiratory Chain Proton gradient formed Four large protein complexes Mitochondria localized Energetically favorable electron.

Packet #28 Chapter #9. Summary Thus Far… At the end of the Krebs Cycle, and before the cell makes more ATP at the electron transport chain, produced so.

Biochemistry 2/e - Garrett & Grisham Copyright © 1999 by Harcourt Brace & Company Chapter 21 Electron Transport and Oxidative Phosphorylation to accompany.

Chapter 14 (Part 1) Electron transport. Chemiosmotic Theory Electron Transport: Electrons carried by reduced coenzymes are passed through a chain of.

DENTAL BIOCHEMISTRY 2015 OXIDATIVE PHOSPHORYLATION Lecture 14 Michael Lea.

Overview of Citric Acid Cycle The citric acid cycle operates under aerobic conditions only The two-carbon acetyl group in acetyl CoA is oxidized to CO.

Chapter 14 - Electron Transport and Oxidative Phosphorylation

Oxidation of glucose and fatty acids to CO 2 Respiration involves the oxidation of glucose and other compounds to produce energy. C 6 H 12 O

Oxidative Phosphorylation. Definition It is the process whereby reducing equivalents produced during oxidative metabolism are used to reduce oxygen to.

Oxidative Phosphorylation and ATP 24.5 ATP Energy from Glucose Chapter 24 Metabolism and Energy Production.

Oxidative Phosphorylation

The respiratory chain: a strategy to recover energy The mitochondrial electron transport chain functioning and control Oxidative phosphorylation Russian.

Oxidative Phosphorylation Pratt and Cornely, Chapter 15.

Cellular Respiration 7.3 Aerobic Respiration.

Metabolic Biochemistry Lecture 8 Aug. 23, 2006 Oxidative Phosphorylation.

Stages of Metabolism.

AP Biology Cellular Respiration Part 2. Is Oxygen present?

OXIDATIVE PHOSPHORYLATION This complex mechanical art form can be viewed as a metaphor for the molecular apparatus underlying electron transport and ATP.

The Proton-Motive Force

The Electron Transport Chain & Chemiosmosis. Aerobic Respiration 1.Glycolysis: C 6 H 12 O 6  2C 3 H 4 O ATP + 2 NADH 2.Krebs: 2C 3 H 4 O 3  6CO.

The Respiratory Chain & Oxidative Phosphorylation.

The Role of Electron Transport in Metabolism

WALT Hydrogen carried by reduced co- enzyme’s enter the Electron Transport chain Synthesis of ATP is associated with the electron transport chain The Electron.

Electron Transport Chain and Oxidative Phosphorylation Dr. Sooad Al-Daihan Biochemistry department.

INTER 111: Graduate Biochemistry.  Define electron transport chain, oxidative phosphorylation, and coupling  Know the locations of the participants.

NADH NAD + H+H+ H+H+ H+H+ H+H+ H+H+ H+H+ H+H+ H+H+ H+H+ H+H+ H+H+ H+H+ H+H+ H+H+ O2O2 O H2OH2O H+H+ H+H+ H+H+ H+H+ H+H+ H+H+ H+H+ Electron Transport ATP.

Outer membrane inner membrane matrix red = respiratory chain proteins green = ATP synthases Figure 1. Location of enzymes involved in oxidative phosphorylation.

Substrate and oxidative phosphorylation. Substrate-level phosphorylation is a type of chemical reaction that results in the formation and creation of.

Glucose metabolism Some ATP Big bonus: NADH, FADH2 → REDUCING POWER

Oxidative Phosphorylation What is it? Process in which ATP is formed as a result of the transfer of electrons from NADH or FADH 2 to O 2 via a series of.

Biochemistry Lecture 14. Energy from Reduced Fuels is Used to Synthesize ATP in Animals Carbohydrates, lipids, and amino acids are the main reduced fuels.

At the end of the electron transport chain, oxygen receives the energy-spent electrons, resulting in the production of water. ½ O e- + 2 H+ → H 2.

Electron Transport Chain (Respiratory Chain) Dr. Sumbul Fatma 1 Lecture Respiratory Block.

Copyright © 2005 Pearson Education, Inc. publishing as Benjamin Cummings What we have made so far in terms of energy GLYCOLYSISBRIDGEKREBS CYCLE.

LEHNINGER PRINCIPLES OF BIOCHEMISTRY

The Proton-Motive Force Chapter 21 Stryer Short Course.

Aim: What is the electron transport chain?

Chapter 14 - Electron Transport and Oxidative Phosphorylation

Complex Organic Molecules Simpler waste products w/ less energy catabolic pathway ATP + H 2 O ADP + P.

Mitochondrial Electron Transport The cheetah, whose capacity for aerobic metabolism makes it one of the fastest animals.

Electron Transport Chain (Respiratory Chain)

Metabolism. Cell Structure Energy for Living ATP and Energy.

Lesson 5 -Electron Transport Chain. Oxidative Phosphorylation Remember, ATP is the universal energy currency of the cell. NADH and FADH 2 reducing power.

Powerpoint Templates Page 1 Powerpoint Templates Page 2 1.Understand the chemiosmotic theory. 2. Determine the inhibitors of the resp. chain. 3. Understand.

AP Biology Cellular Respiration Overview Part 1. Process of Cellular Respiration.

ELECTRON TRANSPORT CHAIN. An electron transport chain (ETC) couples electron transfer between an electron donor (such as NADH ) and an electron acceptor.

Oxidative Phosphorylation

OXIDATIVE PHOSPHORYLATION

Electron Transport Chain and Oxidative Phosphorylation

23.2 Electron Transport and ATP

Oxidative Phosphorylation

Oxidative Phosphorylation Via the Electron Transport Chain

Cellular Respiration Part 2

(7) Cellular Respiration

Oxidative Phosphorylation Results from Cellular Respiration

Electron Transport and Oxidative Phosphorylation

Chapter 18 Metabolic Pathways and Energy Production

Cellular Respiration Part 2

Respiration as Redox Respiration is a redox process that transfers hydrogen from sugar to oxygen. Valence electrons of carbon and hydrogen lose potential.

Electron Transport Chain and Oxidative Phosphorylation

Respiration Transforms Energy

Complex Organic Molecules Simpler waste products w/ less energy

Electron Transport Chain (Respiratory Chain)

Electron Transport Chain (Respiratory Chain)

Harvesting Chemical Energy

Presentation transcript:

Electron Transport Chain (ETC) and Oxidative Phosphorylation (Ox Phos)

ETC and Ox Phos Electron Transport Chain (ETC) AKA respiratory chain importance: allows conversion of reducing equivalents to ATP location: inner mitochondrial membrane

Detailed Mitochondrial Structure

“Sites” are Used to Describe the ETC Molecules not completely known Sites I-IV Overview of the four

Analogy of waterline with valves at various spots Many Well-known Poisons are Poisons of the ETC

Site I in detail NADH FMN Fe-S CoQ 10 Know net reaction and name of “enzyme”

Sites II-IV Know net reactions and names of “enzymes”

Electron Flow per se Does not Cause ATP Synthesis

Q Cycle A proton gradient is developed

Mitchell’s Chemiosmotic Theory Proton gradient tightly coupled to ATP synthase

Fo- oligomycin-sensitive integral membrane portion F1- hexamer of  - and ß-subunits  -subunit estimated to rotate at 7,000 rpm ATP Synthase is an Oligomeric Rotor

Oligomycin others exist Inhibitors of ATP Synthase

2,4-DNP others exist one way of experimentally determining importance of proton gradient Uncouplers of ATP Synthesis

Moles ATP Atoms oxygen Theoretically 3 (NAD) or 2 (FAD) Experimentally 2.8 is a ballpark real number P:O Ratio

Availability of ADP (usually) Regulation of ATP Synthesis