1 Wang haitao March

Loss of one type of sensory input can cause improved functionality of other sensory systems. Whereas this form of plasticity, cross-modal plasticity, is well established, the molecular and cellular mechanisms underlying it are still unclear. blind individuals compensate their lack of visual input by responding to somatosensory or auditory input with improved sensitivity and accuracy. The brain can adapt to sensory deprivation in one modality (e.g., visual cortex) by increasing plasticity and retuning neuronal circuits in other remaining modalities. 2

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4 GluR2-containing receptors GluR2-lacking receptors Rectification index= I (-60 mV)/ I (+40mV)

Methods In vitro whole cell recording Infection of Neocortical Neurons In Vivo In Vivo Microdialysis In Vivo Extracellular Recording Biochemical Analysis Immunohistochemistry 5

VD Drives GluR1 into Layer 4 to Layer 2/3 Synapses of the Barrel Cortex in Juvenile Rats 6 GFP-GluR1

VD Drives GluR1 into Layer 4 to Layer 2/3 Synapses of the Barrel Cortex in Juvenile Rats 7

VD Procedure for 2 Days Occludes LTP in the Barrel Cortex 8

VD did not alter properties of NMDA component and inhibitory component 9

VD Procedure for 2 Days Occludes LTP in the Barrel Cortex 10

Serotonin Mediates VD-Driven Synaptic GluR1 Delivery in the Juvenile Rat Barrel Cortex 11

Serotonin Mediates VD-Driven Synaptic GluR1 Delivery in the Juvenile Rat Barrel Cortex 12

Serotonin Facilitates Synaptic GluR1 Delivery 13

Serotonin Facilitates Synaptic GluR1 Delivery 14

Serotonin Facilitates Synaptic GluR1 Deliveryc 15

VD Induces Phosphorylation of GluR1 at a Site Critical for Its Synaptic Delivery 16

VD Sharpens Functional Whisker-Barrel Map 17

Visual deprivation (VD) drives AMPA receptors into synapses in the rat barrel cortex Seoronin mediates VD-induced facilitation of synaptic AMPA receptor delivery VD increases activation of ERK and increase of phosphorylation of GluR1 at Ser845 VD sharpens the map in the barrel cortex 18

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