10 mV 100 ms 5 s 10 mV 5 s Transient current injection to the cell can toggle its state.

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Presentation transcript:

10 mV 100 ms 5 s

10 mV 5 s

Transient current injection to the cell can toggle its state

I V I V

Climbing FiberParallel Fiber

Climbing fibers response and Ca changes

LTD: Long Term Depression

LTD time course

LTD: specificity PSTH: Post Stimulus Time Histogram

LTD: Properties

Involvement of AMPA receptors in LTD induction. Pairing PF-mediated EPSPs with depolarization of PCs Pairing quisqualate application with depolarization of cultured PCs

Involvement of mGluR1 and PKC in LTD induction. In the presence of antibodies inactivating mGluR1 control The same in knockout mice lacking functional mGluR1 BAPTA PKC (19¯36) PKC(glu 27 ) (19¯36) Control

Mechanism of LTD

SS activity following vestibular stimulation CS activity following optical stimulation

Mechanism of VOR gain change

L7-PKC transgene

Expression of PKC in L7-PKC mice

Glutamate+Depolarization LTD in L7-PKC mice

VOR gain change in L7-PKC mice

Involvement of PKC activation in LTD induction. BAPTA PKC (19¯36) PKC(glu 27 ) (19¯36) Control NOS inhibitor L-NMMA Control