Ion Channels. Cell membrane Voltage-gated Ion Channels voltage-gated because they open and close depending on the electrical potential across the membrane.

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Presentation transcript:

Ion Channels

Cell membrane

Voltage-gated Ion Channels voltage-gated because they open and close depending on the electrical potential across the membrane.

Chemically-gated Ion Channels Ligand-gated ion channels G-protein coupled receptors

Membrane potential

Subunit structure of the voltage-gated sodium channels

Amino acid sequence similarity and phylogenetic relationships of voltage-gated sodium channel  subunits The nine sodium channel isoforms may be considered members of one protein family.

RECEPTOR DATABASE