Dr Shafiq Khan Lab Transforming Growth Factor beta (TGF-  ) signaling How TGF-  promotes tumor progression The role of the different TGF-  isoforms

Dr Jaideep Chaudhary Lab Inhibitors of Differentiation (Id) Promotes tumor progression Viruses causing prostate cancer Pathway of action

Dr Valerie Odero-Marah Lab Snail transcription factor Promotes tumor progression via reactive oxygen species Promotes metastasis to bone

Dr. Cimona V. Hinton Lab PTEN and CXCR4 Studying how loss of tumor suppressors permits metastasis enhancing genes. PTEN usually lost early in cancer progression CXCR4 associated with metastasis

Dr Godwin Ananaba Lab Role of Sterols in prostate cancer How high cholesterol and low phytosterol can promote prostate cancer Using cyclodextran compounds as a delivery system

Sources of Funding  National Institute of Health (NIH): RCMI, P20  National Cancer Institute (NCI): RO1  Department of Defense (DOD): Idea, New Investigator, Pca Training Grant  Georgia Research Alliance (GRA): equipment and personnel

Publications and Presentations  May 2009-April 2010: 11 journal articles  50 presentations in national meetings

Research Facilities  Molecular Biology  Cell Biology  Structural Biology  Histology  Bioinformatics and Biostatistics  Analytical

Collaborative Center for Cancer Genomics (CCGC)  Collaborative effort between Clark Atlanta University and Ovarian Cancer Institute at Georgia Tech  Gene expression analysis of individual patients

Prostate Cancer Tissue Bank  Collaboration between Saint Joseph’s hospital and Georgia Tech  Intend to acquire prostate cancer patient samples for analysis at the Genomics center  Intend to establish a prostate cancer tissue bank