The Department of Pathophysiology Guo lirong

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Presentation transcript:

The Department of Pathophysiology Guo lirong Hypoxia The Department of Pathophysiology Guo lirong

Definition of hypoxia (What is hypoxia?) Parameters of Blood Oxygen Main points to study Definition of hypoxia (What is hypoxia?) Parameters of Blood Oxygen

External respiration Tissue cells Blood Circulation Oxygen Supply Hypoxia External respiration Tissue cells Blood Circulation Oxygen Supply Oxygen Utilization

Hypoxia Definition Hypoxia is the commonest pathological process，which is defined as that cells can not obtain enough oxygen or can not fully utilize oxygen，thus leading to changes in their metabolism，function，or structure.

Parameters of Blood Oxygen Hypoxia Parameters of Blood Oxygen 1.Partial pressure of oxygen（PO2） 2.Oxygen binding capacity（CO2 max） 3.Oxygen content（CO2 ） 4.Oxygen saturation（ SO2 ）

Partial pressure of oxygen（PO2） Hypoxia Partial pressure of oxygen（PO2） 1.Definition：the tension produced by oxygen molecules physically dissolved in plasma. 2.Normal value： PaO2=13.3kPa(100mmHg) PvO2=5.33kPa(40mmHg)

Oxygen binding capacity （CO2max） Hypoxia Oxygen binding capacity （CO2max） 1. Definition：It is the maximum amount of oxygen that can be combined to hemoglobin in 100 ml of blood. 2.Normal value： 20ml/dl

Hypoxia Oxygen content（CO2） 1.Definition：It is the actual content of oxygen in 100ml blood. 2.Normal value： CaO2=19ml/dl CvO2=14ml/dl

Arteriovenous oxygen content (Ca-vO2) Definition: It is the difference of oxygen content between arterial blood and mixed venous blood. Normal value： 5ml/dl 19ml/dl 14ml/dl 5ml/dl O2 A V

= Oxygen saturation (SO2) Hypoxia Oxygen saturation (SO2) Definition: It is the percentage of hemoglobin present as oxyhemoglobin. CO2-dissolved O2 CO2max 100% = SO2 Normal value：SaO2=95%; SvO2=70%

P50 Definition: P50 is a parameter reflecting the affinity of Hb to oxygen; it is the O2 pressure required to sturate 50% of Hb. Normal value：26~28 mmHg

Dissociation curve of oxyhemoglobin Hypoxia Leftward-shifted curve: 20 40 60 80 100 Hb Saturation (%) Rightward-shifted curve pH↓ 2,3-DPG↑ CO2 ↑ Temperature↑ PaO2 (mmHg)

Thank you