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Presentation transcript:

Anthropometry and Breast Cancer Publication van den Brandt, P.A., et al. Pooled analysis of prospective cohort studies on height, weight and breast cancer risk. American Journal of Epidemiology. 2000; 152:

Sweden Mammography Cohort Nurses’ Health Study Netherlands Cohort Study New York State Cohort Iowa Women’s Health Study Canadian National Breast Screening Study Cohort Studies in the Pooled Analysis of Anthropometry and Breast Cancer Total = 337,819 # cases = 4,385 Premeno. = 723 Postmeno. = 3,208 Adventist Health Study

Number of Cases in the Pooled Analysis of Anthropometry and Breast Cancer Study No. of cases Premeno. Postmeno. Adventist Health Canadian National Iowa Women’s 0643 Netherlands Cohort 0420 New York State 0358 Nurses’ Health (a) Nurses’ Health (b) Sweden Mammography van den Brandt et al, 2000

Pooled Multivariate Relative Risks for Breast Cancer and Body Mass Index BMI (kg/m 2 ) RR (95% CI) Premenopausal Postmenopausal < (ref) 1.00 (ref) 21-< ( ) 1.14 ( ) 23-< ( ) 1.15 ( ) 25-< ( ) 1.26 ( ) 27-< ( ) 1.43 ( ) 29-< ( ) 1.21 ( ) 31-< ( ) 1.29 ( ) > ( ) 1.27 ( ) p for trend p-for-interaction = van den Brandt et al, 2000

Study-Specific Relative Risks for Premenopausal Breast Cancer and BMI van den Brandt, et al Relative Risk.5 15 Combined Sweden Nurses' (b) Nurses' (a) Canada

Study-Specific Relative Risks for Postmenopausal Breast Cancer and BMI Relative Risk.812 Combined Sweden Nurses' (b) Nurses' (a) NY State Netherlands Iowa Canada Adventist van den Brandt, et al. 2000

Body Mass Index and Breast Cancer: Pooled Analysis van den Brandt et al, 2000

Pooled Multivariate Relative Risks for Breast Cancer and Height by Menopausal Status Height (m) PremenopausalPostmenopausal < (ref)1.00 (ref) 1.60-< ( )1.09 ( ) 1.65-< ( )1.23 ( ) 1.70-< ( )1.24 ( ) > ( )1.28 ( ) p for trend 0.41 <0.001 p-for-interaction = 0.13 van den Brandt et al, 2000

Study-Specific Relative Risks for Premenopausal Breast Cancer and Height Relative Risk.612 Combined Sweden Nurses' (b) Nurses' (a) Canada van den Brandt et al, 2000

Study-Specific Relative Risks for Postmenopausal Breast Cancer and Height Relative Risk.812 Combined Sweden Nurses’ (b) Nurses’ (a) NY State Netherlands Iowa Canada Adventist van den Brandt, et al. 2000

Pooled Multivariate Relative Risks for Breast Cancer and Height van den Brandt et al, 2000 Relative Risk Height (m)

Van den Brandt et al, 2000 van den Brandt et al, 2000 Height and Breast Cancer: Pooled Analysis