OXIDATIVE STRESS. INDUCTION OF OXIDATIVE STRESS Glutathione conjugation MalnutritionMutation Phagocytic activation Tissue damageSmoking.

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Presentation transcript:

OXIDATIVE STRESS

INDUCTION OF OXIDATIVE STRESS Glutathione conjugation MalnutritionMutation Phagocytic activation Tissue damageSmoking

OXIDATIVE STRESS AND DISEASES Aging Cancers Degenerative disorders: Alzheimer’s disease & Parkinson’s disease Cardiovascular diseases: Atherosclerosis

OXIDATIVE STRESS AND AGING

OXIDATIVE STRESS AND CANCERS Free radicals Oxidation of DNA Free radicals Inhibition of antioxidant defense mechanism

OXIDATIVE STRESS AND PARKINSON’S DISEASE Increased hydrogen peroxide formation increases dopamine oxidation. Decreased glutathione level in substantia nigra. Formation of hydroxy radical by increased iron concentration in substantia nigra. Increased lipid peroxidation in substantia nigra.

OXIDATIVE STRESS AND ALZHEIMER’S DISEASE Normal Aging, Mutations Elevation of  -amyloid  -amyloid polymerization Production of ROS Lipid peroxidation Tau protein formation Neuronal dysfunction

OXIDATIVE STRESS AND ATHEROSCLEROSIS

THERAPEUTIC ANTIOXIDANTS

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