Co-Transporters
Na + /Glucose Symport
Vibrio cholerae Prokaryote Water-bourne pathogen Produces Cholera Toxin
Chloride Ion Channel (CFTR) involved in Cystic Fibrosis CFTR = Cystic Fibrosis Transmembrane conductance Regulator
K = Lysine R = Arginine CFTR Channel Protein
Healthy Lung Lung epithelial cells
Cystic Fibrosis Lung
Misfolded CFTR protein Degraded in ER
CF Gene Therapy Flu virus with Normal CFTR gene
Na + /K + ATP-dependent Active Transporter (Pump) Pg. 396 (see also Fig )
K + “Leak” Channel