Co-Transporters Na + /Glucose Symport Vibrio cholerae Prokaryote Water-bourne pathogen Produces Cholera Toxin.

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Presentation transcript:

Co-Transporters

Na + /Glucose Symport

Vibrio cholerae Prokaryote Water-bourne pathogen Produces Cholera Toxin

Chloride Ion Channel (CFTR) involved in Cystic Fibrosis CFTR = Cystic Fibrosis Transmembrane conductance Regulator

K = Lysine R = Arginine CFTR Channel Protein

Healthy Lung Lung epithelial cells

Cystic Fibrosis Lung

Misfolded CFTR protein Degraded in ER

CF Gene Therapy Flu virus with Normal CFTR gene

Na + /K + ATP-dependent Active Transporter (Pump) Pg. 396 (see also Fig )

K + “Leak” Channel

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