Mendelian pedigree patterns further complications imprinting

Mendelian pedigree patterns further complications imprinting Paternal imprinting: normal function of gene A is associated with epigenetic inactivation of the paternal allele Maternal imprinting: normal function of gene A is associated with epigenetic inactivation of the maternal allele

Mendelian pedigree patterns further complications imprinting Disease phenotype caused by imprinting of the nonimprinted allele loss of imprint Example Phenotype arises only through male transmission

Mendelian pedigree patterns further complications P- M+ P- M+ P- M*+ P- M+ erase imprint paternal imprint erase imprint paternal imprint P- M+ P*+ M+ P- M+