T2* Imaging Asadullah Khan MRI Institute for Biomedical Research

The Projects I am working on: Correlating phase with iron content in Alzheimer’s Disease. Correlating phase with iron content in Alzheimer’s Disease. T2* imaging, its application in quantifying iron and its dependence on high field. T2* imaging, its application in quantifying iron and its dependence on high field.

T2* Imaging The goal of T2* Imaging The goal of T2* Imaging Multi echo magnitude images Multi echo magnitude images R2*(1.5T) = R2 o + R2' = R2 o + 1.5k R2*(1.5T) = R2 o + R2' = R2 o + 1.5k (we find k is about 4/s/T for R2 o = 10/s and R2*(GM) = 15/s) (we find k is about 4/s/T for R2 o = 10/s and R2*(GM) = 15/s) R2*(4.0T) = R2 o + 4.0k (giving T2*=40ms) Phase () = - Phase ( φ ) = - γΔBTE 1.5 T 4.0 T WM 60 msec 50 msec GM 75 msec 40 msec

T1 ImagePhase ImageT2* Image T2* Imaging

Conclusions T2* appears to correlate with iron (possible use in evaluating iron content in certain diseases such as Parkinsons and perhaps Alzheimers) T2* appears to correlate with iron (possible use in evaluating iron content in certain diseases such as Parkinsons and perhaps Alzheimers) Decreased T2* of GM may lead to better T1 contrast (at least for motor cortex and basal ganglia) Decreased T2* of GM may lead to better T1 contrast (at least for motor cortex and basal ganglia) It would be interesting to correlate the iron content predictions of T2*, T2’ and phase It would be interesting to correlate the iron content predictions of T2*, T2’ and phase