The PATCHED (Ptc) Gene Brendan McQuellon. What is PATCH Transmembrane surface receptor Binds ligands of Hedgehog(Hh) family Weinberg, 2007.

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Presentation transcript:

The PATCHED (Ptc) Gene Brendan McQuellon

What is PATCH Transmembrane surface receptor Binds ligands of Hedgehog(Hh) family Weinberg, 2007

Normal Ptc Role Controls cell fate by inhibiting Hh/Shh signaling Inhibits the transcription of Hh/Shh target genes Can regulate the cell cycle

Shh/Ptc/Gli pathway Weinberg, mages/feature-articles/Weekly- Top-10/pub-crawl/sonic- hedgehog.jpg

Shh/Ptc/Gli pathway Weinberg, ature-articles/Weekly-Top-10/pub- crawl/sonic-hedgehog.jpg

Sonic hedgehog and Patched regulate neural development

Sonic hedgehog and Patched regulate neural development

Sonic hedgehog and Patched regulate neural development

Sonic hedgehog and Patched regulate neural development Goodrich et al,

How KO’s were made Goodrich et al., 1997

Heterozygous Mice Goodrich et at., 1997

Heterozygous Mice Goodrich et at., 1997

How does Ptc relate to cancer? Gorlin Syndrome –Basal Cell Carcinomas –Medulloblastomas Sporadic Instances Ionizing Radiation

How does Ptc relate to cancer? Meningiomas, Breast and Esophageal carcinomas Shh/Ptc pathway hyperactive in many other cancers

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