Equivalent Circuit of an Axon Membrane

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Equivalent Circuit of an Axon Membrane

Feedback Amplifier current proportional to difference (E-input) Measured voltage Input Signal Measured Current Feedback Amplifier current proportional to difference (E-input) Hodgkin & Huxley’s voltage clamp of the squid giant axon

Hodgkin & Huxley’s voltage clamp of the squid giant axon: early inward Na late outward K Hodgkin & Huxley’s voltage clamp of the squid giant axon: Current response to hyper-polarization and de-polarization

Hodgkin & Huxley’s voltage clamp of the squid giant axon: late outward K early Na Hodgkin & Huxley’s voltage clamp of the squid giant axon: Current response to hyper-polarization and de-polarization

Hodgkin & Huxley separation of Na and K currents by variation of bath Na concentration

Separation of Na and K Current-Voltage curves

Separation of Na and K Ionic conductance changes Rapid changes in gNa Slow changes in gK Separation of Na and K Ionic conductance changes

Na and K conductance at various voltage clamp steps

Channel openings and closings during Action Potential

Example of time course of changes in n & n^4 ~ gK and m, h & m^3 Example of time course of changes in n & n^4 ~ gK and m, h & m^3*h ~ gNa

Voltage dependence of Hodgkin-Huxley model parameters

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