Solution Copy files from f:\edwin\solution.  21  11  22 1  2 BMD  1 exercise 1 y 3 Hip  11  22  33  44  55 1 42 52 y 5 Arm y 4 Spine y 2 Duration.

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Solution Copy files from f:\edwin\solution

 21  11  22 1  2 BMD  1 exercise 1 y 3 Hip  11  22  33  44  y 5 Arm y 4 Spine y 2 Duration y 1 Intensity

 21  11  22 1  2 BMD  1 exercise  j or  y j 1 y 3 Hip  11  22  33  44  55  y 5 Arm y 4 Spine y 2 Duration y 1 Intensity Genetic + Stratification effects  k or  y k

 2(1)  2(2)  2(3)  2(4)  2(5)  j =,  k =    2(1)  2(2) Common pathway model

 (1) 3(2) 4(1) 4(2) 5(1) 5(2)  (1) 3(2) 4(1) 4(2) 5(1) 5(2)  (3) 3(4) 4(3) 4(4) 5(3) 5(4)  0 3(5) 4(5) 5(5)  j =,  k = Independent pathway

Common pathway model Model fitDifference test -2ll# parameters 22 df.p. Full No genetic No admixture No genetic + no admixture Vs Full Vs no admixture

Independent pathway Model fitDifference test -2ll# parameters 22 df.p. Full No genetic No admixture No genetic + no admixture Vs Full Vs no admixture Independent pathway

Difference test 22 df.p. Full No admixture Common versus independent