1 MT vs CT: 28 day survival Number at risk CT MT day % Surviving Monotherapy (MT) Combination Therapy (CT) Log-rank p-value: Kumar et al, Crit Care Med 2009 (in press)

2 MT vs CT: 28 day pressor liberation MT CT Number at risk Pressor dependence (%) Time (days) Log rank p-value = 0.03 Monotherapy (MT) Combination Therapy (CT) Kumar et al, Crit Care Med 2010;38:1773–85

3 Combination vs Monotherapy: Primary Antibiotic Kumar et al, Crit Care Med 2010;38:1773–85

4 Combination vs Monotherapy: Organisms Kumar et al, Crit Care Med 2010;38:1773–85

5 Combination vs Monotherapy: Secondary Antibiotic Kumar et al, Crit Care Med 2010;38:1773–85

6 Combination vs Monotherapy: Clinical Syndrome Kumar et al, Crit Care Med 2010;38:1773–85