Biomechanics of Nerve. Spinal Peripheral Nerves zNerve fibers z Connective tissue zVascular structures.

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Presentation transcript:

Biomechanics of Nerve

Spinal Peripheral Nerves zNerve fibers z Connective tissue zVascular structures

Mechanical Properties z Resist - compression - tension

Characteristics z Small sensory fibers – pain etc. z Large motor fibers

Intraneural Connective Tissue Endoneurium z surround each fiber - collagen & fibroblasts Perineurium z provides mechanical strength & biomechanical barrier z Epineurium - outermost- protect fascicles, vascular supply

Intraneural Connective Tissue

Spinal Nerve Roots z devoid of: - epineurium - perineurium

Endoneurial Fluid z Interstitial fluid z Trauma   fluid pressure z  circulation  z  conduction

Injuries z Tension 2 0 trauma / child birth z Compression 2 0 to trauma / insidious

Mechanisms vs. Tension Injuries z dependent on perineurium for elasticity z dependent primarily on epineurium

Rabbit Tibial Nerve Elongation Load

Rabbit Tibial Nerve z Initially:low load  significant elongation z Elastic/linear region z disruption of endoneurial tubes & perineurium  rupture

Peripheral Nerves z Maximal elongation at elastic limit – 20% z Complete structural failure at 30% z Injury   stiffness   elasticity

Tensile Injuries to Brachial Plexus

zhigh speed MVA zfall from height zdirect hit to superior shoulder or lateral head (stinger) zchild birth

Nerve Regeneration zNerve rupture before endoneurial tubes & perineurium zpathway for regeneration z1 mm/day

Compression Injuries znumbness, pain, muscle weakness zischemia may be more important than actual compression zduration is important

Mechanisms of Compression Injuries zintermittent or constant low pressure  intraneural edema  fibrotic scar (common in spinal nerves) zproximal compression   axonal transport  distal nerve more susceptible to compression injuries (carpal tunnel)

Mechanisms of Compression Injuries zLarge nerves (motor) affected more zSmall nerves (sensory) spared

Factors influencing damage zDirect vs. indirect zMagnitude zDuration

Regeneration zIntact Schwann Cells zcompletely severed  no guiding structures preserved  no direction of regeneration  loss of sensory and motor function

Regeneration

Effects of Aging Diminished: zVibratory sensation z2 point discrimination zDTRs zNCVs (50-70 m/s in young,  10 m/s in 30-40) z Touch sensation

Effects of Aging z Slightly  pain threshold z  motor function z Functional recovery is less satisfactory