SciFinder ® : Part of the process™ 2006 Edition

SciFinder ® : Part of the process™ 2006 Edition SciFinder ® 2006 provides new, powerful capabilities for scientists New structure searching capabilities New reaction display capabilities New navigation and usability improvements

SciFinder ® : Part of the process™ 2006 Edition SciFinder 2006 provides outstanding new capabilities for scientists New structure searching capabilities New reaction display capabilities New navigation and usability improvements

SciFinder ® : Part of the process™ 2006 Edition Several new structure search capabilities are available Similarity Searching Powerful new query tools New and improved structure search options

SciFinder ® : Part of the process™ 2006 Edition Similarity search ranks all compounds in the CAS Registry SM database via the Tanimoto algorithm Compounds with highest scores included in results Similarity search is complementary to substructure search Similarity searching allows scientists to find new types of answers to their structure questions

SciFinder ® : Part of the process™ 2006 Edition The Tanimoto algorithm utilizes various chemical descriptors Atoms and their direct attachments Atom sequences Bond sequences Degree of connectivity Type of ring fusion Element counts Atom counts Ring counts

SciFinder ® : Part of the process™ 2006 Edition An example of a Tanimoto score calculation QS = Number of query descriptors = 143 FS = Number of file substance descriptors = 169 C = Number of descriptors common to both = 139 Score = 100 * C = 100 * 139 = 80 (QS + FS – C) ( – 139)

SciFinder ® : Part of the process™ 2006 Edition The fewer the differences between query and answer, the higher the score Query

SciFinder ® : Part of the process™ 2006 Edition Similarity searching is accessed via Get Substances

SciFinder ® : Part of the process™ 2006 Edition An analysis is performed based on similarity scores

SciFinder ® : Part of the process™ 2006 Edition Selected answers are presented in similarity score order

SciFinder ® : Part of the process™ 2006 Edition Substances with lower scores show increasing variance with the query

SciFinder ® : Part of the process™ 2006 Edition Substances with lower scores show increasing variance with the query

SciFinder ® : Part of the process™ 2006 Edition New structure query tools are available in SciFinder 2006 Draw a variable attachment point Draw a repeating group

SciFinder ® : Part of the process™ 2006 Edition These new tools are available in the structure editor tool palette New Variable Attachment Position tool New Repeating group tool

SciFinder ® : Part of the process™ 2006 Edition New search options allow scientists to control the relevancy of their answer set Eliminate substances with no literature references Describe literature roles of resulting substances Only retrieve commercially available substances Control the type of substance retrieved by its chemical classification

SciFinder ® : Part of the process™ 2006 Edition SciFinder 2006 provides outstanding new capabilities for scientists New structure searching capabilities New reaction capabilities New navigation and usability improvements

SciFinder ® : Part of the process™ 2006 Edition Reaction searching is being enriched with new content and new features Enhanced access to RXN linking Query highlighting Reaction conditions Elucidation of interim RXN steps Improved search options, including limit by number of steps

SciFinder ® : Part of the process™ 2006 Edition New Reaction search options allow scientists to control the relevancy of their answer set

SciFinder ® : Part of the process™ 2006 Edition Reaction conditions show time, temperature and other parameters

SciFinder ® : Part of the process™ 2006 Edition Intermediate reactions in a multi-step reaction can be conveniently reviewed Click on any substance to check substance details, commercial availability or other reactions where this compound is the product or starting material

SciFinder ® : Part of the process™ 2006 Edition Click any substance in the reaction to get additional information, including retro-synthetic pathways Reactions ►

SciFinder ® : Part of the process™ 2006 Edition Click any substance in the reaction to get additional information, including retro-synthetic pathways

SciFinder ® : Part of the process™ 2006 Edition SciFinder 2006 provides outstanding new capabilities for scientists New structure searching capabilities New reaction display capabilities New navigation and usability improvements

SciFinder ® : Part of the process™ 2006 Edition New navigation and usability improvements make SciFinder a better research tool Duplicate detection and removal Direct to document/Direct to Library Mouse-wheel enabled! New user assistance New navigation windows Quick reference lookup with Locate by Bibliographic Information

SciFinder ® : Part of the process™ 2006 Edition Duplicate detection and removal are useful when searching in both CAplus sm and MEDLINE ® Duplicate references are removed with the click of a mouse!

SciFinder ® : Part of the process™ 2006 Edition Convenient access to source documents is provided by links from every reference, direct to the document or your library!

SciFinder ® : Part of the process™ 2006 Edition New user assistance options will provide in-context help Launched via user assistance button

SciFinder ® : Part of the process™ 2006 Edition New task navigation windows will reduce mouse clicks for scientists All explore options in one window! New Locate capability when looking up something specific

SciFinder ® : Part of the process™ 2006 Edition The Locate feature allows quick access to specific references Journal references or patents can be obtained Input as much or as little of what you know about the reference Journal names, author names, title words and publication date can be combined

SciFinder ® : Part of the process™ 2006 Edition SciFinder has become an essential part of the research process! Convenient access to CAS content –enriched over time with vital content to support discovery research An array of powerful search technologies –supporting a variety of scientists across the research enterprise Enabled with an easy-to-use interface –designed to maximize efficiency for scientists

SciFinder ® : Part of the process™ 2006 Edition