BIPN 148 Lecture 9
How are synaptic changes regulated? Malenka and Nicoll, 1995
Biochemical Basis of LTP
Modulation of NMDA receptors
Calcium signaling and LTP/LTD
Calcium activation of CaM kinases
TTT CatalyticAutoinhibitorySelf-association Inhibitory Calmodulin Binding 286 Autonomous Activity 305/306 Inhibitory A BC PP Structure of CaMKII Verdaguer et al. (1999) Embo. J. 18:
Calcium activation of CaMKII
Persistent activation of CaMKII
NMDA Receptor CaMKII Transient CaMKII Activation Thr 286 Autophosphorylation (persistently active) NMDAR Association (persistently active) CaMKII Ca ++ / CaM Effects of Ca/CaM on CaMKII
CaM Kinase II and potentiation Wang and Kelly 1995
LTP in Thr286A mutant mice
Lissman, 1991 How might CaMKII affect synaptic function?
NR2B interaction with CaMKII
LTP-induced changes in AMPA currents
LTP phosphorylation of AMPA-R