BIPN 148 Lecture 9. How are synaptic changes regulated? Malenka and Nicoll, 1995.

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Presentation transcript:

BIPN 148 Lecture 9

How are synaptic changes regulated? Malenka and Nicoll, 1995

Biochemical Basis of LTP

Modulation of NMDA receptors

Calcium signaling and LTP/LTD

Calcium activation of CaM kinases

TTT CatalyticAutoinhibitorySelf-association Inhibitory Calmodulin Binding 286 Autonomous Activity 305/306 Inhibitory A BC PP Structure of CaMKII Verdaguer et al. (1999) Embo. J. 18:

Calcium activation of CaMKII

Persistent activation of CaMKII

NMDA Receptor CaMKII Transient CaMKII Activation Thr 286 Autophosphorylation (persistently active) NMDAR Association (persistently active) CaMKII Ca ++ / CaM Effects of Ca/CaM on CaMKII

CaM Kinase II and potentiation Wang and Kelly 1995

LTP in Thr286A mutant mice

Lissman, 1991 How might CaMKII affect synaptic function?

NR2B interaction with CaMKII

LTP-induced changes in AMPA currents

LTP phosphorylation of AMPA-R