Bone Resorption The unique ability of self-renewal in bone tissue.

Slides:



Advertisements
Similar presentations
Skeletal System.
Advertisements

Chandler/Brown: Conditioning for Strength and Human Performance© 2008 T. Jeff Chandler and Lee E. Brown Chapter 4 The Skeletal System.
Bone Development and Growth
Andrew Richards & Ryan Swenson.  Endochondral Ossification-”within cartilage” Start with Hyaline cartilage model in similar shape as the bone Primary.
CARTILAGE AND BONE Similarities Living cells embedded in a matrix produced by themselves Cells occupy spaces in the matrix called lacunae Both develop.
SAP2b: Relate structure and function in skeletal system
Bones: The Living Framework of the Human Body Eva L. Murdoch, PhD Assistant Professor Department of Natural Sciences Joliet Junior College
Composition of Bone 50-70% Mineral Hydroxyapatite crystal Ca 10 (PO 4 ) 6 (OH) % Organic Matrix Type I Collagen (90% of total bone protein) Other.
Parathyroid Gland and Related Hormones
Skeletal Muscle LECTURE PACKET 8 READING: CHAPTER 5 COPYRIGHT 2008 PEARSON EDUCATION.
PART 1: BONES. made up of CT, epithelial tissue, & nerve tissue 18% of weight of human body Skeletal System includes bones & cartilage Part 1: Bone Part.
Bone remodeling essential if bones are to retain normal proportions and strength accounts for bones becoming thicker forms large projections for muscles.
Bone Homeostasis: Remodeling and Repair By: Haley Drayer
Cartilage Structure No nerves or blood vessels Surrounded by perichondrium Matrix Lacunae Chondrocyte.
Gross Anatomy  Long Bone. Basic Structure Superior view  Transverse section, diaphysis of an immature long bone.
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings BIOLOGY OF HUMAN AGING CHAPTER 5 The Skeletal System.
Bone Formation, Growth, & Maintenance. Types of Bone Cells  Osteocytes  Mature bone cells  Osteoblasts  Bone-forming cells  Osteoclasts  Bone-destroying.
Osseous Tissue (Bone Tissue). Classification of Bone by Tissue Type Two basic types of Tissue 1. Compact bone Homogeneous Looks “smooth” 2. Spongy bone.
Physiology of Bone Dr Taha Sadig Ahmed Physiology Department College of Medicine, King Saud University.
Physiology of Bone Dr Taha Sadig Ahmed Physiology Department College of Medicine, King Saud University.
Osteocytes Mature bone cells Main cells that perform metabolism Do not undergo cell division.
Bone & Bone Formation Written by : RAYAN S. ALBALLAA Histology team, Group A Edited by: Albara Marwa Histology team, Group A.
6-1 Chapter 6 Skeletal System: Bones and Bone Tissue.
Bone Development & Growth. Intramembranous Bones Forms many flat skull bones, parts of the mandible, and clavicles. Ossification Steps: 1.1 ossification.
Honors Anatomy copy version
Chapter 6: Osseous Tissue and Bone Structure 1. 2.
 Skeletal System: Day Three Bone Formation, Growth, and Remodeling, Bone Diseases and Disorders.
Osseous Tissue (Bone Tissue). 1. Cells Osteocytes— mature bone cells Osteoblasts— bone-forming cells (germ cells or “bud” cells) Osteoclasts —bone-destroying.
Bone Tissue Osteogenic cells: They differentiate into osteoblasts Osteoblasts: Are the bone forming cells. They form organic components of matrix and help.
The Skeletal System. Functions Support  Structural support  Framework for attachment Storage  Calcium reserve  Energy reserves (Lipids in yellow marrow)
Copyright © 2010 Pearson Education, Inc. 6-3 Ossification and appositional growth are mechanisms of bone formation and enlargement.
Bones are alive Living bones: Form Grow Repair Remodel
The Skeletal System: A Closer Look
 Introduction to skeletal system  Functions of skeletal system  Structure of the bone  Bone development Objectives.
Bone Tissue Chapter 6. Functions of Bone Support - surrounding tissue Protect - vital organs and other tissues Movement - attachment for muscles Mineral.
Bone Development & Growth
Physiology of Bone Dr Taha Sadig Ahmed Physiology Department
Welcome To Our Presentation
Physiology of Bone Remodeling Outcomes
Protection: Blood Cell Production: Body Movement: Detoxification: Structural Support: Storage: 1) minerals and 2) lipids Functions of Bone (Osseous.
Chapter 6 Osseous Tissue & Bone Structure
Bones Quiz #1 . Bones Quiz #2  Bones Quiz #3 
The Skeletal System v=yENNqRJ2mu0.
BONE Dr Iram Tassaduq DEFINITION Bone is a specialized connective tissue characterized by mineralized extracellular matrix. Bones are the organs of skeletal.
Osteoporosis. Background Osteoporosis is disorders of the bone, characterized by progressive loss of bone mass and skeletal fragility. Patients with osteoporosis.
Bone maintenance, repair, and physiology. A. Bone remodeling
Bone structure. Bone structure Osteon Stem cells.
About 10% of bone is replaced every year in an adult skeleton
Bone structure.
Skeletal System: Day Three
BONE FORMATION, GROWTH AND REMODELING
Skeletal System: Day Three
Objectives 6 & 7 Structural Unit of compact bone = osteon Osteons (Haversian systems) are elongated cylinders oriented along bone axis Several.
Unit 3 Test Review.
Chapter 4: Osteocytes Lynda F. Bonewald.
Bones are alive Living bones: Form Grow Repair Remodel
The Secrets of its Strength
Osseous Tissue (Bone Tissue)
Bone remodeling Lining cells Bone marrow.
Bone Growth Notes.
Bone Remodeling _______________ units – adjacent osteoblasts and osteoclasts deposit and resorb bone at periosteal and endosteal surfaces.
Skeletal system Chapter 5.
Skeletal System Introduction
The Skeletal System.
Chapter 45 Osteoporosis in AdultsPhoto Album
Skeletal System – Bone Growth
Which of these bones is classified as a flat bone?
Bone Remodeling.
Bone Development Bone Remodeling Bone Homeostasis Skeletal
Ossification (bone formation), remodelling
Presentation transcript:

Bone Resorption The unique ability of self-renewal in bone tissue

Osteoclasts Multinucleated bone cells (many nuclei). Function: to remove damage or old bone tissue by creating an acidic environment between bone surface and cell. Leaves behind an empty space within bone tissue known as a resorption pit.

Osteoblasts Mononucleated bone cells (single nucleus). Function: to deposit a fresh bone matrix in the resorption pit left behind by the osteoclasts. Responsible for the deposition of new bone.

Osteocytes Osteoblasts which become stuck in the fresh bone matrix they have recently laid down. Communication between osteocytes is vital for bone tissue health. Disruptions within this communication network signals for bone to be remodeled or replaced. Lacuna- Space in which individual osteocytes reside within bone tissue. Canaliculus- Cellular protrusion which connect individual osteocytes with one another. Forms a communication network within bone tissue.

Osteoclasts Osteoblasts Osteocytes Osteoblast activity must equal osteoclast activity Summary of Bone Cells

Remodeling Why does bone need to be remodeled? – It has become hypermineralized (old) or had been damage. How does bone know it needs to under go remodeling? – Disruption in osteocyte communicate initiates the process of bone remodeling. Steps of Bone Remodeling 1.Osteoclasts resorb bone. 2.Osteoblasts deposit fresh bone matrix 3.Osteoblasts become embedded within this matrix, transitioning into osteocytes. 4.Communication has been re-established.

Blood Vessel Lining cells Osteocytes Osteoblasts Osteoclasts Microcrack Osteocyte apoptosis Local factors Cement line New bone Animation: Bajaj D. Ph.D., adapted from Bone Remodeling/Repair Bone

Osteoporosis Osteoporosis is an age related skeletal disease. Osteoporosis means “porous bone”. About 10 million Americans are diagnosed with Osteoporosis, of which 80% are women.

Courtesy of Michael J. Klein, M.D. Fritton & Schaffler, 2008 “Bone Quality” HealthyOsteoporotic

Pharmaceutical Countermeasures of Osteoporosis How can drugs alter this process of bone remodeling? – Bisphosphonates, which inhibits bone resorption (osteoclast activity). – Parathyroid Hormone, which stimulates bone formation (osteoblast activity).

Inhibition of Bone Resorption How do Bisphosphonates Function? Ruffled Border Osteoclast Apoptosis Absence of Ruffled Border Animation by Bajaj, D. Ph.D.

To think about: Why is bone resorption vital to bone health? What can happen if bone cell activity is not balanced? How can drugs treat this imbalance in bone cell activity which is observed in Osteoporosis?