C-myc Presented by Tavia Clark. c-Myc: The Quintessential Oncogene Transcription factor involved in: –Cell growth –Cell proliferation –Repression of gene.

Slides:

Advertisements

Similar presentations

Cancer A class of non-infectious diseases occurring when cell cycle control mechanisms fail. Prefix: Onco.

Advertisements

The Story of Bcl-2 Linking cell apoptosis to tumor metastasis Crystal structure of Bcl-2 complex By Yaming Wang.

Myc Lymphoma and Osteosarcoma By Patti Williams. What is Myc?  Located on Chromosome 8q24 (3 exons)  A proto-oncogene  Stimulates the transcription.

HOXA9 – AcuteMyeloidLeukemia. HOX Genes encode transcription factors

E2A and acute lymphoblastic leukemias (ALL). A closer look at the E2A gene... Other names: TCF3, ITF1, and Factors E12/E47 Located on chromosome 19 Encodes.

Notch1 and pre-T-cell Acute Lymphoblastic Leukemia (T-ALL) by Lindsey Wilfley.

Theories of cancer genesis

Molecular Pathology – Cell cycle Dr. Leonard Da Silva Senior Lecturer Molecular & Cellular Pathology.

BRCA2 Blue: Rad51; Green: BRCA2

Transforming Growth Factor-Beta Receptor 2 TGF-β receptor 2

Generation of Oncogenes The major ways of generating oncogenes: Proliferation stimulating gene acquired by a virus. Proviral insertional mutagenesis places.

The Loss of the Cell Cycle Control in Cancer

Cellular oncogenes.

Cancer Cell cycle, oncogenes and tumour suppressors Jake Turner.

The Role of Bcl-2 in Apoptosis and Cancer Eddie Alcorn.

Malignant Melanoma and CDKN2A

The Myc Transcription Factor

NF-  B SOLID TUMORS HEMATOLOGICAL MALIGNANCIES Multiple Myeloma Mantle Cell Lymphoma MALT Lymphoma Diffuse Large B-cell Lymphoma Hodgkin’s Lymphoma Myelodysplasic.

Viruses and Cancer BTY328: Virology

Tumorigenesis and Cancer Development Pin Ling ( 凌斌 ), Ph.D. ext 5632; References: 1.Chapter 23 Cancer in “Molecular Cell Biology”

Tumorigenesis to Cancer Development Pin Ling ( 凌斌 ), Ph.D. ext 5632; References: 1.Chapter 23 Cancer in “Molecular Cell Biology”

Apoptosis (Programmed Cell Death). Apoptosis vs Necrosis Level of stress, change in environment stress apoptosisnecrosis.

STAT3 and the Immune System Maureen Sherry Lynes February 29, 2012.

Neoplasia Lecture 3 Dr. Maha Arafah Dr. Abdulmalik Alsheikh, MD, FRCPC.

Cancer --an Overview  Cell Division  Hormones and Cancer  Malignant Transformation  Angiogenesis and Metastasis  Growth.

Neoplasia Lecture 4 Dr. Maha Arafah Dr. Abdulmalik Alsheikh, MD, FRCPC CARCINOGENESIS Foundation block 2014 Pathology.

MYC’s role in Osteosarcoma & Lymphoma

Human Biology Sylvia S. Mader Michael Windelspecht

Cancer, Oncogenes and Tumour suppressor Genes 1 Dr. Mohamed M. Sayed-Ahmed.

Chapter 4 Cellular Oncogenes ~ Mar 22, 2007.

TGF-β Receptor I/ALK5: An Attractive Therapeutic Target in Tumor Development By Jake Bridgers.

Group Number: 2 Britney Porter, Sandra Nguyen, Eduardo Vargas and Samender Singh Randhawa.

Brent Hoffman. HOXA9 is one of the HOX transcription factors regulating Anterior to Posterior patterning in early development.

Cancer When cell division goes wrong……. Growing out of control, cancer cells produce malignant tumors Cancer is a general term for many diseases in.

CANCER, ONCOGENES AND TUMOUR SUPPRESSOR GENES PHL 425 Dr. Mohamed M. Sayed-Ahmed 1/1/2015.

All cells in a person have the same DNA Yet eye cells differ from nose cells Central dogma of biology Genetic engineeri ng Tissue therapy.

BRG-1 in Cancer BRG-1 is an ATPase subunit of the SWI/SNF class of chromatin remodeling complexes It has been found mutated in a number of cancer cell.

Therapeutic miRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model Janaiah Kota,1 Raghu R. Chivukula,2 Kathryn A. O’Donnell,3,4 Erik A.

ROLE OF GENE EXPRESSION:  Activation of a gene that results in a protein  Cells DO NOT need to produce proteins for every code. GENOME:  Complete genetic.

E2A and Acute Lymphoblastic Leukemia (ALL) Jeremy Petree.

Javad Jamshidi Fasa University of Medical Sciences, November 2015 Session 9 Medical Genetics Cancer Genetics.

Cancer “whiteboard” presentation ●Name of cancer (what type), where can it occur? ●Function of body part that it affects ●Causes (genetic, environmental…)?

Neoplasia 4 Dr. Hiba Wazeer Al Zou’bi. 4- Nuclear Transcription Factors: DNA transcription regulated by genes e.g. MYC, MYB, JUN, FOS, REL oncogenes 

PTEN (Cowden Syndrome) /.../ sld083.htm.

Hematopoietic Cancers Common Disruptions

ONCOGENE AND ITS ROLE IN THE DEVELOPMENT OF LEUKAEMIA Nouf khaled al-Hajjar SUPERVISOR Dr.SAMINA HAQ.

c-Myc A Biological Paradox

Mouse Double Minute 2 (MDM2)

Ch 21 & 19 Gene Mutations Cancer.

Table of Contents Section 1 Control of Gene Expression

Neoplasia lecture4 Dr Heyam Awad FRCPath.

Dr. Peter John M.Phil, PhD Atta-ur-Rahman School of Applied Biosciences (ASAB) National University of Sciences & Technology (NUST)

FASTING INHIBITS THE GROWTH OF CANCER CELLS INVOLVES P53

G0S2 Represses PI3K/AKT/mTOR Signaling and Increases Sensitivity to PI3K/mTOR Pathway Inhibitors in Estrogen Receptor-Positive Breast Cancer Cells Christina.

Incidence of nonskin cancers at five years

The Role of Myc A Master Regulator Gone Awry

ARF and p16: One Locus, Two Tumor Suppressors

Regulator of the apoptotic pathway

Bcl-2: A Matter of Life-or-Death

(T-cell Acute Lymphoblastic Leukemia)

The great MYC escape in tumorigenesis

A New FOXO Pathway Required for Leukemogenesis

Aim: What do you want to know about cancer? (addressing your concerns)

CAS, the Human Homologue of the Yeast Chromosome-Segregation Gene CSE1, in Proliferation, Apoptosis, and Cancer Ulrich Brinkmann The American Journal.

Autocrine IL-6 Signaling: A Key Event in Tumorigenesis?

Canonical gliomagenesis mediators EGFR, P53, and retinoblastoma protein (RB1) are important for cancer signaling. Canonical gliomagenesis mediators EGFR,

C-MYC controls expression of ABC drug transporters in CD34+ hematopoietic progenitors. c-MYC controls expression of ABC drug transporters in CD34+ hematopoietic.

Attacking Cancer at Its Root

LRH-1 controls cell proliferation in antiestrogen-sensitive and antiestrogen-resistant breast cancer. LRH-1 controls cell proliferation in antiestrogen-sensitive.

In vivo efficacy of JAK inhibition in transformed Pax5+/− pro-B cells harboring Jak3V670A. In vivo efficacy of JAK inhibition in transformed Pax5+/− pro-B.

Presentation transcript:

C-myc Presented by Tavia Clark

c-Myc: The Quintessential Oncogene Transcription factor involved in: –Cell growth –Cell proliferation –Repression of gene transcription –Apoptosis –Angiogenesis

TABLE 1 Growth inhibition and apoptosis following treatment with antisense oligonucleotides to c-myc Growth inhibitionApoptosis Cell or Tumorin vivoin vitroin vivoin vitroReference Human acute lymphoblastic leukemia (CEM-C7) Burkitt's lymphoma lines 30 Ramos (EBV−) + + Daudi (EBV+) + − Small cell lung cancer lines GLC4, GLC4-cDDP a, GLC4-Adr + −46 Human erythroblasts + −47 Human CML blasts b ++??48 Melanoma lines c , 50 Thyroid cancer lines + ?51 Orbital fibroblasts + −52 Monomyeloid cells (HL-60) Burkitt's lymphoma (Daudi, ST486) + ?53 Ovarian cancer lines + +e+e 54 d Lymphoma U e Breast Cancer MCF Ewing's sarcoma CHP Burkitt's lymphoma ST Breast cancer (MCF-7, MDA-MB-231) + ?56 Human T lymphocytes +IL-2 or PHA + −57 Burkitt lymphomas (ST486, JD38) + ?58 Hematopoietic cells + ?59 Esophageal cancer cells *Symbols: +, effect tested for and seen; −, effect tested for and not seen; ?, not tested (or not reported)

Links 5?cookieSet=1http://arjournals.annualreviews.org/doi/full/ /annurev.physiol ?cookieSet= Y0Y3F- 1&_user=130907&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct= C &_version=1&_urlVersion=0&_userid=130907&md5=aa23778e e7ca3420a6b4cb277d165126http:// 44Y0Y3F- 1&_user=130907&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct= C &_version=1&_urlVersion=0&_userid=130907&md5=aa23778e e7ca3420a6b4cb277d htmlhttp://news-service.stanford.edu/news/2004/october13/med-felsher html

Articles Bruno Amati, Konstantinos Alevizopoulos and Jaromir Vlach, “MYC and the Cell Cycle,” Frontiers in Bioscience, 3, d (1998) Jonas A Nilsson and John L Cleveland, “Myc pathways provoking cell suicide and cancer,” Oncogene, 22, (2003) J Craig Cohen, et. al. “Transient in utero knockout (TIUKO) of C- MYC affects late lung and intestinal development in the mouse,” BMC Developmental Biology, 4:4 (2004) E. Brad Thompson, “The many roles of c-Myc in apoptosis,” Annual Review of Physiology, 60, (1998) Werner Lutz, Javier Leon and Martin Eilers, “Contributions of Myc to tumorigenesis,” BBA Reviews on Cancer, 1602:1, (2002) Amy Adams “Switching off cancer gene turns cells healthy in mice,” Sanford Report, October 13, 2004 Bruna Pucci, Margaret Kasten, and Antonio Giordano, “Cell cycle and apoptosis,” Neoplasia 2:4, (2000)