Cytoskeleton IV Chapter 16
Mechanochemical cycle of myosin
DVD clip 74
Striated vs. smooth muscle cells
Thick and thin filaments in smooth muscle cells
Skeletal muscle cells form by the fusion of many muscle cell precursors called myoblasts 50 micrometers wide, several cm long
Skeletal muscle cells in rats showing blue stained nuclei
Skeletal Muscle Myofibrils
Closeup of two sarcomeres
Schematic diagram showing components of dark and light bands
Insect flight muscle viewed in cross section show myosin and actin packed together
Sliding filament model of muscle contraction
Accessory proteins in a sarcomere
Ion Channels at Neuromuscular Junction
Ca2+ release channel is opened by transmembrane protein in tubule
Two membrane system that relays signal to contract muscle cells
Electron micrograph showing 2 T tubules
Muscle contraction is controlled by troponin troponin can pull tropomyosin of myosin binding sites
Ca 2+ relieves tropomyosin blockage
Cell Cycle and Programmed Cell Death Chapter 17
The cell cycle can be studied in a cell free system
The cell cycle is often studied in immortalized mammalian cell lines
Activation of a cyclin dependent kinase
CdK activity can be suppressed by inhibitory phosphorylation
CdK activity can be suppressed by inhibitory proteins
Cell fusion experiments
Assembly of pre-replicative complex during G1 phase
Entry into mitosis is blocked by incomplete DNA replication Hydroxyurea blocks DNA synthesis Caffeine causes failure of checkpoint
The Rb protein acts as a brake in mammalian cells
Overview of cell cycle control system