Immunology Overview. Innate vs Acquired Immunity Non-specific, rapid Physical, Chemical Barriers Complex Biochemical Mechanisms –Fever –Inflammation –Complement.

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Presentation transcript:

Immunology Overview

Innate vs Acquired Immunity Non-specific, rapid Physical, Chemical Barriers Complex Biochemical Mechanisms –Fever –Inflammation –Complement –Toll and Nod Antigen specific and initially slow Memory Lymphocytes Humoral and Cellular Exquisitely Specific Recognition molecules

Eukaryote Innate Immunity

Cells of the Immune System

The Immune System

The Clonal Selection Theory

Primary vs Secondary Response

Antigenicity Antigen - any molecule that binds to and activates the specific receptors of lymphocytes –Immunogenicity –Specificity Epitopes Some molecules (haptens) have specificity but no immunogenicity -- these need a carrier –Digoxigenin –peptides

DIG - KLH

Requirements for Immunogenicity Foreignness High Molecular Weight Chemical Complexity Degradability Host Factors –Genetics –Route of encounter / Adjuvants

Protein Structure

Myoglobin Epitopes

Lysozyme Epitopes

Compare Epitope Structures

Antibody Structure

The 5 Antibody Classes

Mammalian Antibody Isotypes

The Immunoglobulin Superfamily

The Central Dogma

and GOD said, “Let there be light chains!”

Light chain exon rearrangement

“and let there be heavy chains!”

The Clonal Selection Theory

Monoclonal Antibodies