Allergy and Hypersensitivity K. J. Goodrum 2006. Types of Immune Hypersensitivity Reactions.

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Presentation transcript:

Allergy and Hypersensitivity K. J. Goodrum 2006

Types of Immune Hypersensitivity Reactions

Properties of Inhaled Allergens

Penetration of epithelial Barriers by Allergens

Early IL-4 response promotes Th2 development that drives B cell class switching to IgE

Signaling through Stat6 is necessary for Th2 responses. Th2 cells support IgE responses.

Antigen binding to IgE on mast cells leads to amplification of IgE production

Mast cell activation affects many tissues

Molecules released upon activation of mast cells

Toxic granule proteins and inflammatory substances released upon activation of eosinophils

Acute vs. late phase inflammatory responses

TH2 mediated chronic inflammation in Asthma

Treatment approaches for IgE-mediated Allergy

Type II Cytotoxic reaction

Immune Complex mediated local inflammation such as in Arthus Reaction

Serum Sickness: an Immune complex disease

Type IV Hypersensitivity Reactions

Stages of a Type IV Hypersensitivity Reaction

Th1 derived cytokines and chemokines direct Type IV reactions

Allergic Contact Dermatitis: A type IV reaction

Blistering skin lesions on hand of patient with poison ivy contact dermatitis (a type IV reaction)

Granulomatous inflammation is a consequence of chronic Type IV reactions

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