The Eight Phases of Inflammation

Slides:

Advertisements

Similar presentations

Inflammation The local response of the body to an irritant Purpose

Advertisements

Capillary Circulation & Edema Formation

1 Antigens combine with antibodies to form antigen- antibody complexes Antigen Antibody Antigen-antibody complex.

10.1 The Body’s Lines of Defence

Microcirculation and inflammation M. Jurajda. Anatomy of capillary bed.

An Overview of the Body’s Defenses. The first line of defense, the skin and mucous membranes, prevents most microbes from entering the body.

Inflammation and Repair

Chapter 4 Inflammation and Repair.

Chapter 10: Tissue Response to Injury

Ebola Clip. The Lymphatic and Immune Systems Day 1.

Biology of Disease CH0576 The Inflammatory Response I Dr Stephen Todryk.

Physical and Chemical Barriers to Infection Week 12.

Lymphatic System The Body’s Defense System. Nonspecific Defense First Line of Defense –Skin –Mucous Membrane –Secretions.

Lymphatic and Immune System The Body’s Defense. Nonspecific Defense First Line of Defense –Skin –Mucous Membrane –Secretions.

1 Chapter 20 Defenses Against Disease: The Immune System.

Unit 6 Healing and Inflammation.  What seems to happen at the injury site?  What happens to the brain?

Review of Inflammation and Fever 1. Inflammation 2 A non-specific response to injury or necrosis that occurs in a vascularized tissue. Signs: Redness,

Immune System. Means of Defense (3 categories) First two are Nonspecific A. Barriers –Doesn’t distinguish between agents –Helps Prevent Entry into the.

Lecturer: Dr. Maha Arafah

Lecture 23 Immune System. Introduction A human or animal must defend itself against multitude of different pathogens including viruses, bacteria, fungi,

Nonspecific immune defenses The immune system protects your body from pathogens.

The First and Second Lines of Defense Against Disease BY JEFF HOFFMAN.

Unit 6 Healing and Inflammation.  Injury is a part of athletic participation  All athletes have to learn how to cope with of injuries that may temporarily.

Chapter 3 Inflammation and Repair.

Chapter 13 Leukocyte Activation and Migration Dr. Capers

Announcements Exams- Extra Credit - Lab 5 - Lymphatic System.

Blood, Sweat and Tears Also, mucus, stomach acids, skin, nasal secretions, and saliva.

Tutorial 1 Inflammation and cellular responses. Inflammation Is a protective response The body’s response to injury Interwoven with the repair process.

Human Anatomy and Physiology

Chapter 4 Injury, Inflammation, and Repair. Review of Structure and Function The body is capable of undergoing dynamic changes to carry out body functions.

Immunity Biology 2122 Chapter 21. Introduction Innate or nonspecific defense: – First-line of defense – Second-line of defense The adaptive or specific.

Introduction to pathology Inflammation lecture 1

The Immune System Dr. Jena Hamra.

The Inflammatory Response A review. The 3 Lines of Defense FIRST line: Barrier protection – non-specific (treats each pathogen the same) – acts to prevent.

 Primary Response: tissue destruction directly associated with traumatic force; can’t change amount of initial damage  Secondary Response: occurs from.

INFLAMMATION All information taken directly from Understanding Zoonotic Diseases by Janet Amundson Romich. Thomson Delmar publishing.

The Immune System Chapter 43 ~. PCA: List the organs involved in the immune sytem:

AP Biology Immune / Lymphatic System lymphocytes attacking cancer cell phagocytic leukocyte lymph system Fighting the Enemy Within!

Why is the Circulatory System Important? 1. Transport of oxygen and carbon dioxide (why are these gases important?) 2.Transport nutrients and wastes. Sugars,

Concepts of Healing.  m97yvyk.

(Inflammatory Response)

TISSUE RESPONSE TO INJURY Tissue Healing. THE HEALING PROCESS Inflammatory Response Phase  (4 days)  Injury to the cell will change the metabolism (cellular.

Inflammation Dr. Ahmad Hameed MBBS,DCP, M.Phil. Definition Inflammation is a protective response involving host cells, blood vessels, proteins and other.

Inflammation Chapter 12 Copyright © 2014 by Mosby, an imprint of Elsevier Inc.

TISSUE RESPONSE TO INJURY BTEC Extended Diploma in Sport (Performance and Excellence)

Tissue Response to Injury: Inflammation, Swelling, and Edema

The Blood. Functions The transportation of dissolved gases, nutrients, hormones, and metabolic waste. The regulation of the pH and Ion composition of.

Bodies Response to Injury There are 3 phases of healing. Inflammation Inflammation Repair/Regeneration Repair/Regeneration Remodeling Remodeling.

The Inflammatory Response

Tissue Repair Clot Clean up Scab Restored blood supply Granulation

Tissue Response to Injury

INFLAMMATION What is inflammation?

Inflammation (1 of 5) Ali Al Khader, M.D. Faculty of Medicine

Nonspecific External and Internal Defenses

Soft Tissue Healing.

Chapter 43 The Immune System.

Injury Response Process

Acute inflammation 2 By Dr. S. Homathy.

Tissue Response to Injury

Animal Form & Function Immune System

Tissue Healing Sports Medicine 1/2.

The Immune System Chapter 43 ~.

Innate Immunity Fever is an abnormally high body temperature due to resetting of the hypothalamic thermostat. Non-specific response: speeds up body reactions.

TISSUE RESPONSE TO INJURY

Chapter 14 Immune Response in Space and Time

Chapter 35 Innate Immunity.

Pathophysiology For Pharmacy students.

Presentation transcript:

The Eight Phases of Inflammation

The Eight Phases of Inflammation Injury Utrastructural Changes Metabolic (Hypoxic) Changes Activation of Chemical Mediators Hemodynamic Changes Permeability Changes Leukocyte Migration Phagocytosis

Phases of Inflammation Injury - any event that impairs tissue structure Trauma (most sports injuries) macrotrauma (impact, contact) microtrauma (overuse, friction)

Phases of Inflammation Ultrastructural Changes disruption of the cell membrane contents of cell spill into extracellular spaces caused by trauma hypoxia

Phases of Inflammation Metabolic (Hypoxic) Changes cells become deprived of oxygen (secondary hypoxic injury) sodium pump fails sodium increases in cell cell membrane disruption contents spill out

Phases of Inflammation Activation of Chemical Mediators Chemical mediators (histamine, bradykinin) spill out of the cell Chemical mediators notify body that cells have been damaged mobilize the body=s resources to handle the situation modify and regulate the rest of the inflammatory response

Phases of Inflammation Hemodynamic Changes arteries dilate enhancing blood flow inactive capillaries and venules open total blood flow increases, rate of flow decreases leukocytes fall out of stream line and adhere to vessel wall

Phases of Inflammation Permeability Changes sizable gaps develop in the vessel walls. leukocytes escape to injury site

Phases of Inflammation Leukocyte Migration leukocytes migrate in concentration-limited fashion more chemical mediators, more leukocytes 2 types of leukocytes neutrophils travel fast, arrive first temporary first line of defense live 7 hours macrophages second line of defense live for months

Phases of Inflammation Phagocytosis process of digesting cellular debris into pieces small enough to be removed by the lymph vessels.