Protein Therapeutics: a summary and pharmacological classification

Slides:

Advertisements

Similar presentations

Soma Mukherjee SMU,Chemistry 5 th April’2011.  Introduction : Protein & important structural features for therapeutics.  Development  Classification.

Advertisements

Manipulation of the Immune Response Chapter 14

Overview of Protein Therapeutics 1. Contents Introduction 1 Production 2 Delivery 33 Future Direction 44.

1. Within a few years, more than half of newly approved medicines will be biopharmaceuticals. To ensure safety and efficacy, the FDA created a daunting.

Biopharmaceutical Products Touqeer Ahmed Ph.D. Atta-ur-Rahman School of Applied Bioscience, National University of Sciences and Technology 23 rd September,

A Brief History of Biotechnology and its Uses in Industry.

Proteomics Understanding Proteins in the Postgenomic Era.

What is biological therapies Biological therapy is the therapeutic use of agents derived from biological sources and affecting biologic response. Also.

HISTORY OF MEDICAL BIOTECHNOLOGY CHANGES IN THE LAST 15 YEARS.

Cancer Vaccines Medicines that belong to a class of substances known as biological response modifiers. Biological response modifiers stimulate or restore.

LO: Be able to describe what gene therapy is and how it could be used.

Biotechnology Unit 6. I. What is biotechnology? Biotechnology is a the use of living systems and organisms to develop or make useful products. Today we.

Genetics, Biotechnology and Biomedical Engineering

Biotechnology SB2.f – Examine the use of DNA technology in forensics, medicine and agriculture.

Biotechnology and Medicine Esmaeil Sadroddiny, PhD Medical Biotechnology.

The Human Genome and Gene Technologies

Gene Therapy. What is Gene Therapy? Defective genes make non-functional proteins, creating genetic disorders Gene therapy corrects defective genes by.

Biotechnology in Medicine Chapter 12.

Diseases Learning Targets and Success Criteria. Infection Learning Target I can explain how viruses, bacteria, fungi and parasites may infect the human.

Naked DNA By Amber Spiering, Amit Khosla, Jason Powell, Liz Viola, Dan Poor, Lisa Smith.

Investigational Drugs in the hospital. + What is Investigational Drug? Investigational or experimental drugs are new drugs that have not yet been approved.

Anti-mRNA Strategies What is the antisense oligonucleotides? - Synthetic genetic material. - Interacts with natural genetic material (DNA or RNA) prevent.

HISTORY The term "proteomics" was first coined in 1997 to make an analogy with genomics, the study of the genes.genomicsgenes Proteome = protein + genome.

DNA Technology Bio Summarize the process of gel electrophoresis as a technique to separate molecules based on size. Students should learn the general.

BIOLOGY 12 Biotechnology. What is Biotechnology? biotechnology is technology based on biology biotechnology harnesses cellular and biomolecular processes.

Gene Technology Genetic engineering is one of the newest concepts that is trying to solve issues in the areas of agriculture, medicine and the human genome.

Recombinant DNA technology

What is Biotechnology? “a collection of technologies that use living cells and/or biological molecules to solve problems and make useful products”

Boundless Lecture Slides Free to share, print, make copies and changes. Get yours at Available on the Boundless Teaching Platform.

Gene Therapy. Gene Therapy is a technique for correcting defective genes responsible for disease development Gene Therapy is a technique for correcting.

Recombinant DNA. Review Restriction enzymes cut DNA molecules at certain ‘restricted’ points A plasmid is also cut at the same point The ends match up.

Developing medicines for the future and why it is challenging Angela Milne.

 How does DNA help us in medicine? QOTD. Mr.Dunnum DNA TECHNOLOGY.

Gene Therapy Clinical Trials. Cancer Gene Therapy Three Basic Approaches. Genetically alter a person's immune cells that are already naturally targeted.

Recombinant DNA What is the basis of recombinant DNA technology? How does one “clone” a gene? How are genetically modified organisms (GMOs) created? Illustration.

What is gene therapy? Do now: In your own words,

At the end of this lesson you should be able to 1. Define Genetic Engineering 2. Understand that GE alters DNA 3. Understand the function of restriction.

ROOMINA MAZHAR Ph. D. Botany. INTRODUCTION Peptides and proteins are known to have great therapeutic potential against several diseases and syndromes.

Biotechnology in North Carolina. Biotechnology in N.C. What is biotechnology ? A collection of technologies that use living cells and/or biological molecules.

At the end of this lesson you should be able to 1. Define Genetic Engineering 2. Understand that GE alters DNA 3. Understand the function of restriction.

In most gene therapy studies, a "normal" gene is inserted into the genome to replace an "abnormal," disease-causing gene. A carrier molecule called a.

Gene Therapy. antisense oligonucleotides(ODNs) antisense oligonucleotides(ODNs) Ribozymes Ribozymes DNAzymes DNAzymes RNA interference(RNAi). RNA interference(RNAi).

BIOTECHNOLOGY Gene Sequencing (Human Genome Project) Cloning Stem Cell Research Gene Therapy DNA Fingerprinting (and other Forensics applications)

Pharmaceutical Biotechnology

Wednesday 3/8/17 AIM: How does biotechnology help investigate the living world? DO NOW: What is biotechnology? Can you give examples and explain how.

DIAGNOSIS OF DISEASES AND GENE THERAPY

Protein therapeutics.

What are Biopharmaceuticals?

Drug Discovery &Development

Biologic Medicines.

Proteins have the most dynamic and diverse role of any macromolecule in the body

Objectives – Adaptive Immunity

BIOLOGY 12 Biotechnology.

Introduction and Definitions

Introduction to Pharmacology

What are Biopharmaceuticals?

Globular Protein Made of amino acid chains

What is ... Gene Therapy?.

Gene Therapy By: Ashley Hale & Cody Stevens.

Biomedical Therapies Foundation Standard 1: Academic Foundation

Genetic Engineering The simple addition, deletion, or manipulation of a single trait in an organism to create a desired change.

Market and R&D Analysis of Recombinant Protein Drugs.

applications Agriculture

Anti-therapeutic antibodies Creative Biolabs is a pioneer and undisputed global leader in the rapidly emerging market for therapeutic antibodies. We offer.

Therapeutic antibodies Creative Biolabs is a pioneer and undisputed global leader in the rapidly emerging market for therapeutic antibodies. We offer a.

Anti-therapeutic antibodies Creative Biolabs is a pioneer and undisputed global leader in the rapidly emerging market for therapeutic antibodies. We offer.

Monday’s Writing Topic ~ Week 20 – January 25 – 29 ~

Biotechnology Genetic Engineering

What is Biotechnology? “a collection of technologies that use living cells and/or biological molecules to solve problems and make useful products”

GENE EXPRESSION.

Presentation transcript:

Protein Therapeutics: a summary and pharmacological classification Benjamin Leader, Quentin J. Baca and David E. Golan Yiben Wang 11/16/11

Protein Therapeutics: -25,000-40,000 different genes in the human genome -Alternative splicing of genes -Post-translational modifications -Very high number of functionally distinct proteins Disease View: -Immense challenge: -One protein is mutated or abnormal -Present in high or low concentrations Therapeutic View: -Tremendous opportunity 130 different proteins or peptides – FDA approval

Advantages of protein therapeutics: Proteins – highly specific and complex set of functions -Chemical compounds can’t mimick Specificity -Less chance of interference; reduce adverse effects Natural production -Well tolerated; no immune response Diseases – gene is deleted or mutated -Replacement treatment – no gene therapy (Unavailable) Faster FDA approval time -2003: 1980-2002  33 therapeutic proteins, 294 small-molecule drugs (>1year) Unique form and function -Companies – patent protection

Functional classification of protein therapeutics: Group I -Protein therapeutics with enzymatic or regulatory activity Group II -Protein therapeutics with special targeting activity Group III -Protein vaccines Group IV -Protein diagnostics

Group I: Protein therapeutics with enzymatic or regulatory activity Ia: Replacing a protein that is deficient or abnormal Ib: Augmenting an existing pathway Ic: Providing a novel function or activity

Group II: Protein therapeutics with special targeting IIa: Interfering with a molecule or organism IIb: Delivering other compounds or proteins

Group III: Protein vaccines IIIa: Protecting against a deleterious foreign agent IIIb: Treating an autoimmune disease IIIc: Treating cancer

Group IV: Protein diagnostics

Challenges for protein therapeutics: Protein solubility, route of administration, distribution, and stability. Immune response. Physiologically active – post-translational modifications. Costs 5. Ethics

Recombinant human proteins: -FDA – biotechnology medicines: -Monoclonal antibodies -Natural interferons -Vaccines -Hormones -Modified natural enzymes -Cell therapies More work needs to be done.