NACC National Alzheimer’s Coordinating Center NACC Update ADC Director’s Meeting October 2003

NACC National Alzheimer’s Coordinating Center New NACC Faculty Thomas Koepsell, MD, MPH –New Co-Director in competitive renewal –Too many credentials to list… Annette Fitzpatrick, PhD –Asst. Professor, Epidemiology –Previously with CHS and GEM studies –Years of coordinating center experience

NACC National Alzheimer’s Coordinating Center Cumulative totals, additions and active subjects in MDS Total IDs38,28942,46552,41655,807 62,114 Autopsy Total New IDs Found IDs (514) 1824 Active IDs ,422

NACC National Alzheimer’s Coordinating Center Clinical Dementia status of 2003 MDS Subjects Dementia40,273 (64.8%) MCI or questionable 5756 (9.3%) Neuro-control 1937 (3.1%) Control 9335 (15.0%) Other 5495 (7.3%) Unknown 318 (0.5%)

NACC National Alzheimer’s Coordinating Center Neuropathology data Add cases as ready: No Data Call –Edits of past cases –Web browser data entry –other means of input Database “frozen” twice/yr for reports –Director certified data Current data viewable on web Neuropathology leads the way…..

NACC National Alzheimer’s Coordinating Center NACC Collaborative Projects New Award: D. Tsuang, MD –Clinical, pathologic and genetic characteristics of DLB Thirteen NACC projects funded to date Productivity increasing –Nine papers –Fifteen abstracts Thank you!

NACC National Alzheimer’s Coordinating Center NACC and Clinical Data Expansion Implement the Uniform Data Set –Data base structure –Web-based and other I/O –Submit as needed; no data calls –Prospective visits only –Longitudinal follow-up Seamless integration –NP data –MDS

NACC National Alzheimer’s Coordinating Center Continuous Consultation Coverage Methodologic & statistical consultation Database management Secondary analysis from database –ADC investigators encouraged –NACC: initiation or support function Web-site improvements –Training video capabilities

NACC National Alzheimer’s Coordinating Center NACC Competing Continuation Seems like only yesterday… Due November 1 Continuing Improvements –Support –Data access –UDS: standardized, accumulated, longitudinal data Increased investigator opportunity through data sharing