McDaniels – Sept 26, 2008

Outline Patient 5 Exam 6 ADC uncertainty Manuscript

Patient 5 Exam 6

Uncertainty in ADC Standard Deviation from image ROI histogram Slope calculated using extreme points from b=520 and 850 b=0 point retained

Uncertainty in ADC value

Uncertainty in ADC Values

Manuscript : Slice Matching The Diffusion Weighted (DW) image corresponding to each Treatment Plan (TP) image was chosen prior to transcription of the lesion contour. Absolute vertical positioning of each MR slice was unreliable for selection due to an undefined point of reference between the two images. Slice selection was based on comparison of anatomical landmarks within the image. Relative shape and structure of ventricles, sulci and other physical attributes were used for comparison. The DW image most closely matching the pertinent TP image was chosen based on the visual comparison. Typically, the TP imaging was performed at a higher resolution that the DW image. This meant that the slice thickness and spacing were generally less than the 5mm slice thickness and 7mm spacing of the DW images. In general, there were fewer DW slices transecting the lesion than there were TP slices. In that case, the closest matching TP image was paired with each DW image for analysis. TP images not matched with a corresponding DW image were not included to avoid redundancy in the ADC calculation.